# Reactome

License: permissive (CC0-1.0); Mdexa hosting: link-only. Second pass: license_status: looser by the source's own words (looser-explicit): 【标准许可误作自定义条款】许可协议第1条c款写明全部数据及其派生文件采用 CC0，可复制、修改、分发，甚至用于商业，无需许可；插图等为 CC BY 4.0；软件为 Apache 2.0。唯一的"特别许可"针对 FoamTree 软件的本地安装，属配套软件（第21条），不参与数据状态。"不同意即不得使用"是接受条款，不是甲类限制。数据部分没有甲类句，按原文应为 permissive（标识 CC0-1.0），插图部分 CC BY 4.0 带 attribution；比拟定更宽，原文明示，交采纳环节放宽。 | commercial_use: looser by the source's own words (looser-explicit): 原文明示数据"even for commercial purposes"可用，按原文应为 yes。 | derivatives: looser by the source's own words (looser-explicit): 原文明示可修改（modify），按原文应为 yes。 | redistribution: looser by the source's own words (looser-explicit): 原文明示可分发（distribute），按原文应为

- Commercial use: Yes · Derivatives: Yes · Redistribution: Yes · File on Mdexa: No
- License status: Permissive (CC0-1.0)
- Mdexa hosting: Link only — License permissive, judged by public rules and checked by a second-pass model. Link only.
- Last verified: 2026-11-14
- Card: https://mdexa.com/datasets/reactome/

## Key facts

- Domain: Genomics and omics
- Content type: Databases
- Size: —
- Language: English
- Modality: Text
- Publisher: Reactome
- Year: —

## Commercial use of Reactome

- Commercial use: Yes.
The overall verdict takes the strictest part; the parts carry different licenses, listed below.
- License status: Permissive.
- Conditions: Attribution, Notice kept
- License part: Pathway Illustrations, Icon Library, Art, and Branding Materials — Permissive (CC-BY-4.0)
- License part: Software and Code — Permissive (Apache-2.0)
- License part: Data — Permissive (CC0-1.0)
- License part: This Reactome — Permissive (CC-BY-4.0)
- License part: FoamTree (Voronoi Treemaps) — Permissive (NOASSERTION)
Verdicts record what sources state and are not legal advice.

## Reactome license evidence

all parts permissive; conditions are the union of the parts

- **Terms of use page**: Statement found in snapshot s02 (page) — "This License Agreement (the “Agreement”) governs the use of the Reactome database and its contents, including all data, graphics, software, and other materials associated therewith." — https://reactome.org/license (2026-11-13; Page opened)
- **Terms of use page**: Statement found in snapshot s02 (page) — "If you do not agree with the terms of this Agreement, you may not use Reactome." — https://reactome.org/license (2026-11-13; Page opened)
- **Terms of use page**: Statement found in snapshot s02 (page) — "User agrees that the content on Reactome is governed by various open-source licenses and agrees to adhere to applicable license terms as follows:" — https://reactome.org/license (2026-11-13; Page opened)
- **Terms of use page** — CC-BY-4.0: Statement found in snapshot s02 (page) — "This Reactome content is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0)" — https://reactome.org/license (2026-11-13; Page opened)
- **Terms of use page**: Statement found in snapshot s02 (page) — "User may copy, modify, and distribute these materials, provided that appropriate credit is given, a link to the license is included, and any modifications made by User are clearly indicated." — https://reactome.org/license (2026-11-13; Page opened)
- **Terms of use page** — Apache-2.0: Statement found in snapshot s02 (page) — "all Reactome software is licensed under the Apache License 2.0" — https://reactome.org/license (2026-11-13; Page opened)
- **Terms of use page**: Statement found in snapshot s02 (page) — "Individual repositories are marked with the appropriate licensing requirements, and User must ensure their intended use is compliant with the relevant license, as applicable." — https://reactome.org/license (2026-11-13; Page opened)
- **Terms of use page** — CC0-1.0: Statement found in snapshot s02 (page) — "All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0)" — https://reactome.org/license (2026-11-13; Page opened)
- **Terms of use page**: Statement found in snapshot s02 (page) — "User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission." — https://reactome.org/license (2026-11-13; Page opened)
- **Terms of use page**: Statement found in snapshot s02 (page) — "Attribution is encouraged but not required." — https://reactome.org/license (2026-11-13; Page opened)
- **Terms of use page**: Statement found in snapshot s02 (page) — "Notwithstanding the Applicable Open-Source Licenses set out in Section 1 above, User agrees to the application of Special Licenses to certain Reactome content as follows:" — https://reactome.org/license (2026-11-13; Page opened)
- **Terms of use page**: Statement found in snapshot s02 (page) — "The FoamTree software, used to construct the ReacFoam genome-wide pathway overview, is provided under license by Carrot Search, Inc." — https://reactome.org/license (2026-11-13; Page opened)
- **Terms of use page**: Statement found in snapshot s02 (page) — "Images and analyses generated on the Reactome website using FoamTree software are free to use with no restriction." — https://reactome.org/license (2026-11-13; Page opened)
- **Terms of use page**: Statement found in snapshot s02 (page) — "For local installations of the Reactome, User must either: i) use the free, fully functional demo version of the FoamTree software included with Reactome, which adds a promotional logo to one of the cells of the visualization; or ii) obtain their own license from Carrot Search directly." — https://reactome.org/license (2026-11-13; Page opened)
- **Terms of use page**: Statement found in snapshot s02 (page) — "Reactome is provided “as is” and “as available” without any warranties of any kind, either express or implied." — https://reactome.org/license (2026-11-13; Page opened)
- **Terms of use page**: Statement found in snapshot s02 (page) — "Users must comply with all applicable licensing requirements and ensure that their access and/or use of Reactome content is consistent with the terms of this Agreement." — https://reactome.org/license (2026-11-13; Page opened)
- **Terms of use page**: Statement found in snapshot s02 (page) — "© 2026" — https://reactome.org/license (2026-11-13; Page opened)
- **Terms of use page**: Statement found in snapshot s02 (page) — "This Reactome content is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0) ." — https://reactome.org/license (2026-11-13; Page opened)
- **Dataset page** — CC0-1.0: Part "Data" found in snapshot s02 (page) — "c) Data : All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0) ." — https://reactome.org/license (2026-11-13; Page opened)
- **Dataset page** — CC-BY-4.0: Part "Pathway Illustrations, Icon Library, Art" found in snapshot s02 (page) — "a) Pathway Illustrations, Icon Library, Art, and Branding Materials . This Reactome content is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0) ." — https://reactome.org/license (2026-11-13; Page opened)

## Source and lineage

—

## Known issues with Reactome

—

## Preflight

Not run (data not ingested).

## Downloading Reactome and API access

Mdexa does not serve files. Original source:
- https://reactome.org/
- https://reactome.org/license

### Access recipe

- Latest: V98

## Citing Reactome

No recommended citation text.

## Machine-readable

- JSON: https://mdexa.com/datasets/reactome.json
- 2026-11-14 Listed on 2026-11-14. Judged by public rules and checked a second time before listing. The two passes disagreed; the stricter reading is carried: Second pass: license_status: looser by the source's own words (looser-explicit): 【标准许可误作自定义条款】许可协议第1条c款写明全部数据及其派生文件采用 CC0，可复制、修改、分发，甚至用于商业，无需许可；插图等为 CC BY 4.0；软件为 Apache 2.0。唯一的"特别许可"针对 FoamTree 软件的本地安装，属配套软件（第21条），不参与数据状态。"不同意即不得使用"是接受条款，不是甲类限制。数据部分没有甲类句，按原文应为 permissive（标识 CC0-1.0），插图部分 CC BY 4.0 带 attribution；比拟定更宽，原文明示，交采纳环节放宽。 | commercial_use: looser by the source's own words (looser-explicit): 原文明示数据"even for commercial purposes"可用，按原文应为 yes。 | derivatives: looser by the source's own words (looser-explicit): 原文明示可修改（modify），按原文应为 yes。 | redistribution: looser by the source's own words (looser-explicit): 原文明示可分发（distribute），按原文应为 yes。

## Practical information

### Content scope

- The page states that Reactome comprises 16,503 human reactions organized into 2,889 pathways involving 32,565 proteins and modified forms of proteins encoded by 11,496 different human genes, 16,325 complexes, 2,178 small molecules, and 1,103 drugs.
  > Reactome comprises 16,503 human reactions organized into 2,889 pathways involving 32,565 proteins and modified forms of proteins encoded by 11,496 different human genes, 16,325 complexes, 2,178 small molecules, and 1,103 drugs.
  https://reactome.org/about/news (2026-11-13)
- The page states that these reactions were projected onto 83,732 orthologous proteins, creating 20,751 orthologous pathways in 14 non-human species.
  > We have projected these reactions onto 83,732 orthologous proteins, creating 20,751 orthologous pathways in 14 non-human species.
  https://reactome.org/about/news (2026-11-13)

### Identifiers

- The download page lists a stable identifiers database.
  > Stable identifiers database
  https://reactome.org/download-data (2026-11-13)
- The page lists the entry UniProt to pathways.
  > UniProt to pathways
  https://reactome.org/download-data (2026-11-13)
- The page lists the entry ChEBI to pathways.
  > ChEBI to pathways
  https://reactome.org/download-data (2026-11-13)
- The page lists the entry ENSEMBL to pathways.
  > ENSEMBL to pathways
  https://reactome.org/download-data (2026-11-13)
- The page lists the entry miRBase to pathways.
  > miRBase to pathways
  https://reactome.org/download-data (2026-11-13)
- The page lists the entry NCBI to pathways.
  > NCBI to pathways
  https://reactome.org/download-data (2026-11-13)
- The page lists the entry GtoP to pathways.
  > GtoP to pathways
  https://reactome.org/download-data (2026-11-13)
- The page lists the entry Reactome to OMIM.
  > Reactome to OMIM
  https://reactome.org/download-data (2026-11-13)
- The page lists the entry BioModels to Pathways.
  > BioModels to Pathways
  https://reactome.org/download-data (2026-11-13)

### Access

- Web interface only: https://reactome.org/about/news
- Bulk download: https://reactome.org/download-data
- Database dump: https://reactome.org/download-data
- Web interface only: https://reactome.org/license

### Versions

- The page states that the Zenodo download directory is created for every Reactome release quarterly, starting from version 89 (06/2024), and contains download files.
  > The Zenodo download directory is created for every Reactome (reactome.org) release quarterly, starting from version 89 (06/2024), containing download files.
  https://reactome.org/download-data (2026-11-13)
- The page notes that, as of Reactome V94, the Events in BioPAX level 2 format will no longer be available.
  > Note: As of Reactome V94, the “Events in BioPAX level 2 format" will no longer be available.
  https://reactome.org/download-data (2026-11-13)
- The page notes that, as of Reactome V94, the Protégé 2.0 ontology files will no longer be available.
  > Note: As of Reactome V94, the “Protégé 2.0 ontology files” will no longer be available.
  https://reactome.org/download-data (2026-11-13)

### Known defects and misuse

- The page states that interactions are inferred between all protein components of a complex and that, to limit the creation of false-positive inferences, only complexes with four or fewer protein components are considered.
  > Interactions are inferred between all protein components of a complex. To limit the creation of false-positive inferences, only complexes with four or fewer protein components are considered.
  https://reactome.org/download-data (2026-11-13)

### Suited for

- The page states that the services and software tools are designed for biologists, bioinformaticians, and software developers.
  > Our services and software tools are designed for biologists, bioinformaticians, and software developers.
  https://reactome.org/about/news (2026-11-13)
- The page states that the Reactome FIViz app and ReactomeGSA package provide tools for multi-omics data analysis.
  > The Reactome FIViz app and ReactomeGSA package provide tools for multi-omics data analysis.
  https://reactome.org/about/news (2026-11-13)

### No sourced statement yet

Latest version, Unsuited tasks, Commercial licensing

## Continue in this database

This record is one of 109 processed and verified records (datasets, data resources and open models). To find others, call `https://mcp.mdexa.com/v1/datasets?q=<words>` or connect the MCP server at `https://mcp.mdexa.com/mcp`; no key is needed for 20 calls per minute. Rows are under 1 KB; an empty result means "not listed". For a list of items, one batch check (free account) returns a report. Guide: /agents.md. Similar records: STRING (https://mdexa.com/datasets/string/); AlphaFold Protein Structure Database (https://mdexa.com/datasets/alphafold-db/); GEO (https://mdexa.com/datasets/geo/).