# UniProt License: permissive (CC-BY-4.0); Mdexa hosting: link-only. first-hand data-scope statement(s) allow commercial use and redistribution - Commercial use: Yes · Derivatives: Yes · Redistribution: Yes · File on Mdexa: No - License status: Permissive (CC-BY-4.0) - Mdexa hosting: Link only — License permissive, judged by public rules and checked by a second-pass model. Link only. - Last verified: 2026-11-13 - Card: https://mdexa.com/datasets/uniprot/ ## Key facts - Domain: Genomics and omics - Content type: Databases - Size: — — 154,222,205 entries - Language: English - Modality: Text - Publisher: UniProt Consortium - Year: 2026_04 ## Commercial use of UniProt - Commercial use: Yes. - License status: Permissive. - Conditions: Attribution Verdicts record what sources state and are not legal advice. ## UniProt license evidence first-hand data-scope statement(s) allow commercial use and redistribution - **Terms of use page** — CC-BY-4.0: Statement found in snapshot s10 (terms-page) — "We have chosen to apply the Creative Commons Attribution 4.0 International (CC BY 4.0) License to all copyrightable parts of our databases." — https://www.uniprot.org/help/license (2026-11-13; Page opened) - **Terms of use page**: Statement found in snapshot s10 (terms-page) — "We cannot provide unrestricted permission regarding the use of the data, as some data may be covered by patents or other rights." — https://www.uniprot.org/help/license (2026-11-13; Page opened) - **Terms of use page**: Statement found in snapshot s10 (terms-page) — "Any medical or genetic information is provided for research, educational and informational purposes only." — https://www.uniprot.org/help/license (2026-11-13; Page opened) ## Source and lineage — ## Known issues with UniProt - Publisher states it makes no warranties about the correctness of the data and disclaims liability for damages resulting from its use. - The license help page snapshot shows only a generic fallback message, not the license text. ## Preflight Not run (data not ingested). ## Downloading UniProt and API access Mdexa does not serve files. Original source: - https://www.uniprot.org/ - https://www.uniprot.org/help/license ### Access recipe - Latest: 2026_04 (2026-11-04) - Swiss-Prot xml · https://ftp.uniprot.org/pub/databases/uniprot/current_release/knowledgebase/complete/uniprot_sprot.xml.gz - Swiss-Prot fasta · https://ftp.uniprot.org/pub/databases/uniprot/current_release/knowledgebase/complete/uniprot_sprot.fasta.gz - Swiss-Prot text · https://ftp.uniprot.org/pub/databases/uniprot/current_release/knowledgebase/complete/uniprot_sprot.dat.gz - TrEMBL xml · https://ftp.uniprot.org/pub/databases/uniprot/current_release/knowledgebase/complete/uniprot_trembl.xml.gz - TrEMBL fasta · https://ftp.uniprot.org/pub/databases/uniprot/current_release/knowledgebase/complete/uniprot_trembl.fasta.gz - TrEMBL text · https://ftp.uniprot.org/pub/databases/uniprot/current_release/knowledgebase/complete/uniprot_trembl.dat.gz - Isoform sequences fasta · https://ftp.uniprot.org/pub/databases/uniprot/current_release/knowledgebase/complete/uniprot_sprot_varsplic.fasta.gz - UniRef100 xml · https://ftp.uniprot.org/pub/databases/uniprot/uniref/uniref100/uniref100.xml.gz - UniRef100 fasta · https://ftp.uniprot.org/pub/databases/uniprot/uniref/uniref100/uniref100.fasta.gz - UniRef90 xml · https://ftp.uniprot.org/pub/databases/uniprot/uniref/uniref90/uniref90.xml.gz - UniRef90 fasta · https://ftp.uniprot.org/pub/databases/uniprot/uniref/uniref90/uniref90.fasta.gz - UniRef50 fasta · https://ftp.uniprot.org/pub/databases/uniprot/uniref/uniref50/uniref50.fasta.gz ```sh curl -L --create-dirs -o "uniprot_sprot.xml.gz" "https://ftp.uniprot.org/pub/databases/uniprot/current_release/knowledgebase/complete/uniprot_sprot.xml.gz" curl -L --create-dirs -o "uniprot_sprot.fasta.gz" "https://ftp.uniprot.org/pub/databases/uniprot/current_release/knowledgebase/complete/uniprot_sprot.fasta.gz" curl -L --create-dirs -o "uniprot_sprot.dat.gz" "https://ftp.uniprot.org/pub/databases/uniprot/current_release/knowledgebase/complete/uniprot_sprot.dat.gz" curl -L --create-dirs -o "uniprot_trembl.xml.gz" "https://ftp.uniprot.org/pub/databases/uniprot/current_release/knowledgebase/complete/uniprot_trembl.xml.gz" curl -L --create-dirs -o "uniprot_trembl.fasta.gz" "https://ftp.uniprot.org/pub/databases/uniprot/current_release/knowledgebase/complete/uniprot_trembl.fasta.gz" curl -L --create-dirs -o "uniprot_trembl.dat.gz" "https://ftp.uniprot.org/pub/databases/uniprot/current_release/knowledgebase/complete/uniprot_trembl.dat.gz" curl -L --create-dirs -o "uniprot_sprot_varsplic.fasta.gz" "https://ftp.uniprot.org/pub/databases/uniprot/current_release/knowledgebase/complete/uniprot_sprot_varsplic.fasta.gz" curl -L --create-dirs -o "uniref100.xml.gz" "https://ftp.uniprot.org/pub/databases/uniprot/uniref/uniref100/uniref100.xml.gz" curl -L --create-dirs -o "uniref100.fasta.gz" "https://ftp.uniprot.org/pub/databases/uniprot/uniref/uniref100/uniref100.fasta.gz" curl -L --create-dirs -o "uniref90.xml.gz" "https://ftp.uniprot.org/pub/databases/uniprot/uniref/uniref90/uniref90.xml.gz" curl -L --create-dirs -o "uniref90.fasta.gz" "https://ftp.uniprot.org/pub/databases/uniprot/uniref/uniref90/uniref90.fasta.gz" curl -L --create-dirs -o "uniref50.fasta.gz" "https://ftp.uniprot.org/pub/databases/uniprot/uniref/uniref50/uniref50.fasta.gz" ``` ## Citing UniProt No recommended citation text. ## Machine-readable - JSON: https://mdexa.com/datasets/uniprot.json - 2026-11-14 Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is. - 2026-11-14 Practical fields (scope, identifiers, access methods, versions, known defects) were added by the automated pipeline from stored page snapshots; every statement carries a verbatim quote. - 2026-11-14 Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is. - 2026-11-14 Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is. - 2026-11-14 Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is. - 2026-11-14 Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is. - 2026-11-14 Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is. - 2026-11-13 Listed on 2026-11-13. Judged by public rules and checked a second time before listing. These pages could not be retrieved: the UniProt FTP knowledge base README and the UniRef README (connection timed out), and the help pages on API access and downloads (they returned only a script shell). The conclusion rests on the pages that were retrieved: the UniProt license page and the release notes. ## Practical information ### Content scope - UniProtKB Release 2026_04 consists of 154,222,205 entries, with 576,073 entries in UniProtKB/Swiss-Prot and 153,646,132 entries in UniProtKB/TrEMBL. > UniProtKB Release 2026_04 consists of 154,222,205 entries (UniProtKB/Swiss-Prot: 576,073 entries and UniProtKB/TrEMBL: 153,646,132 entries) https://ftp.uniprot.org/pub/databases/uniprot/current_release/relnotes.txt (2026-11-13) - The UniRef100 part of Release 2026_04 consists of 227,086,028 entries. > UniRef100 Release 2026_04 consists of 227,086,028 entries https://ftp.uniprot.org/pub/databases/uniprot/current_release/relnotes.txt (2026-11-13) ### Access - Bulk download: https://www.uniprot.org/downloads - Web interface only: https://www.uniprot.org - Web API: https://rest.uniprot.org/help/programmatic_access - Web API: https://rest.uniprot.org/help/license ### Versions - The announced UniProt Knowledgebase (UniProtKB) release is Release 2026_04, dated 04-Nov-2026. > is pleased to announce UniProt Knowledgebase (UniProtKB) Release 2026_04 (04-Nov-2026). https://ftp.uniprot.org/pub/databases/uniprot/current_release/relnotes.txt (2026-11-13) - UniProt announced in its 2025 NAR paper the intention to restrict unreviewed (TrEMBL) entries to reference proteomes, expecting an initial drop in unreviewed entry counts; excluded sequences remain in UniParc. > It is our intention in 2025 to limit the unreviewed sequences in UniProtKB/TrEMBL to only those derived from reference proteomes https://pmc.ncbi.nlm.nih.gov/articles/PMC11701636/ (2026-11-13) - Earlier, proteome-redundancy reduction has removed proteins from redundant proteomes since release 2015_04. > Methods to reduce proteome redundancy have been in effect since release 2015_04. https://rest.uniprot.org/help/proteome_redundancy (2026-11-13) - UniRef clustering changed in 2013: before then there was no 80% overlap threshold, so older clusters were more length-heterogeneous. > Prior to 2013 there was no overlap threshold, so clusters were more heterogeneous in length. https://rest.uniprot.org/help/uniref (2026-11-13) ### Known defects and misuse - Schnoes et al. found Swiss-Prot near 0% misannotation for most of 37 enzyme families, while TrEMBL, GenBank NR and KEGG showed 5%–63% average misannotation across six superfamilies. > the two other protein sequence databases (GenBank NR and TrEMBL) and the protein sequences in the KEGG pathways database exhibit similar and surprisingly high levels of misannotation that average 5%–63% across the six superfamilies studied. https://pmc.ncbi.nlm.nih.gov/articles/PMC2781113/ (2026-11-13) - UniProt states TrEMBL entries are computationally annotated by automated systems, unlike reviewed Swiss-Prot entries. > In the latter, entries are computationally annotated by automated systems. https://pmc.ncbi.nlm.nih.gov/articles/PMC11701636/ (2026-11-13) ### Suited for - UniProt recommends UniRef90/UniRef50 for similarity searches because they reduce redundancy while keeping full sequence-space coverage (about 58% and 79% size reduction). > UniRef, especially UniRef90 and UniRef50, decreases sequence redundancy compared to UniProtKB and UniParc, while maintaining complete coverage of the sequence space. https://rest.uniprot.org/help/uniref_blast_use (2026-11-13) ### No sourced statement yet Update cycle, Unsuited tasks, Commercial licensing ## Continue in this database This record is one of 109 processed and verified records (datasets, data resources and open models). To find others, call `https://mcp.mdexa.com/v1/datasets?q=` or connect the MCP server at `https://mcp.mdexa.com/mcp`; no key is needed for 20 calls per minute. Rows are under 1 KB; an empty result means "not listed". For a list of items, one batch check (free account) returns a report. Guide: /agents.md. Similar records: AlphaFold Protein Structure Database (https://mdexa.com/datasets/alphafold-db/); GEO (https://mdexa.com/datasets/geo/); gnomAD (https://mdexa.com/datasets/gnomad/).