# ESM C

ESM C. Code: MIT; weights: unverifiable. Last verified 2026-11-14. Query directly over MCP or API.

## Code license

Permissive · MIT
Commercial use: Yes · derivatives: Yes · redistribution: Yes

> Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the “Software”), to deal in the Software without restriction
https://raw.githubusercontent.com/evolutionaryscale/esm/main/LICENSE.md (2026-11-13)

> Copyright 2026 Chan Zuckerberg Biohub, Inc.
https://raw.githubusercontent.com/Biohub/esm/main/LICENSE.md (2026-11-13)

## Weights license

Unverifiable · NOASSERTION
Commercial use: unverified · derivatives: unverified · redistribution: unverified

> License: other
https://huggingface.co/EvolutionaryScale/esmc-300m-2024-12 (2026-11-13)

> "license:mit","license:other"
https://huggingface.co/biohub/ESMC-300M (2026-11-13)

## Commercial use of ESM C

- Code: Yes
- Weights: Unverified
The code license and the weights license stand apart; a verdict on one does not carry over to the other.
Verdicts record what sources state and are not legal advice.

## Limits on outputs

- The model card's out-of-scope section prohibits any use barred by the Acceptable Use Policy.
  > Any use that is prohibited by the Acceptable Use Policy
  https://huggingface.co/biohub/ESMC-300M (2026-11-13)

## Training data

- ESM C is trained on protein sequences from UniRef, MGnify, and the Joint Genome Institute (JGI).
  > ESM C is trained on protein sequences from UniRef, MGnify, and the Joint Genome Institute (JGI).
  https://www.evolutionaryscale.ai/blog/esm-cambrian (2026-11-13)
- ESMC was trained on UniRef, MGnify and JGI sequences clustered at 70% identity (83M, 372M and 2B clusters respectively).
  > ESMC was trained on protein sequences from UniRef, MGnify, and the Joint Genome Institute (JGI).
  https://huggingface.co/biohub/ESMC-300M (2026-11-13)

## How to run

- Weights download: https://huggingface.co/EvolutionaryScale/esmc-300m-2024-12
- Hosted API: https://biohub.ai
- Third-party hosting: https://github.com/Biohub/esm/blob/1b3e08025b/LICENSE.md

## Versions

- unspecified: code —, weights —
- unspecified: code —, weights —
- 304: code —, weights —

## No sourced statement yet

Overlap with benchmarks

https://mdexa.com/models/esm-c/

## Continue in this database

This record is one of 109 processed and verified records (datasets, data resources and open models). To find others, call `https://mcp.mdexa.com/v1/datasets?q=<words>` or connect the MCP server at `https://mcp.mdexa.com/mcp`; no key is needed for 20 calls per minute. Rows are under 1 KB; an empty result means "not listed". For a list of items, one batch check (free account) returns a report. Guide: /agents.md. Similar records: ESM3 open (esm3-sm-open-v1) (https://mdexa.com/models/esm3-open/); AlphaFold 3 (https://mdexa.com/models/alphafold3/); Boltz (Boltz-1 and Boltz-2) (https://mdexa.com/models/boltz/).