# ESM-2

ESM-2. Code: MIT; weights: MIT. Last verified 2026-11-14. Query directly over MCP or API.

## Code license

Permissive · MIT
Commercial use: Yes · derivatives: Yes · redistribution: Yes

> MIT License
https://raw.githubusercontent.com/facebookresearch/esm/main/LICENSE (2026-11-13)

## Weights license

Permissive · MIT
Commercial use: Yes · derivatives: Yes · redistribution: Yes

> License: mit
https://huggingface.co/facebook/esm2_t33_650M_UR50D (2026-11-13)

## Commercial use of ESM-2

- Code: Yes
- Weights: Yes
The code license and the weights license stand apart; a verdict on one does not carry over to the other.
Verdicts record what sources state and are not legal advice.

## Training data

- The repository page lists ESM-2 checkpoints esm2_t36_3B_UR50D and esm2_t48_15B_UR50D together with the entry UR50 (sample UR90).
  > ESM-2 esm2_t36_3B_UR50D() esm2_t48_15B_UR50D() UR50 (sample UR90)
  https://github.com/facebookresearch/esm (2026-11-13)

## How to run

- Weights download: https://huggingface.co/facebook/esm2_t33_650M_UR50D

## Versions

- ESM-2: code MIT, weights MIT

## No sourced statement yet

Limits on outputs, Overlap with benchmarks, Known defects and misuse

https://mdexa.com/models/esm2/

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