# OpenFold3

OpenFold3. Code: Apache-2.0; weights: Apache-2.0. Last verified 2026-11-14. Query directly over MCP or API.

## Code license

Permissive · Apache-2.0
Commercial use: Yes · derivatives: Yes · redistribution: Yes

> Apache License
https://raw.githubusercontent.com/aqlaboratory/openfold-3/main/LICENSE (2026-11-13)

## Weights license

Permissive · Apache-2.0
Commercial use: Yes · derivatives: Yes · redistribution: Yes

> The OpenFold3-preview model is released under Apache 2.0 license.
https://huggingface.co/OpenFold/OpenFold3 (2026-11-13)

## Commercial use of OpenFold3

- Code: Yes
- Weights: Yes
The code license and the weights license stand apart; a verdict on one does not carry over to the other.
Verdicts record what sources state and are not legal advice.

## Training data

- The README states that the full training data for reproducing OpenFold3-preview includes a reproduction of the MGnify-based 13M-sequence distillation dataset described in the AlphaFold3 paper.
  > We provide the full training data for reproducing OpenFold3-preview, including our reproduction of the MGnify-based 13M-sequence distillation dataset described in the AlphaFold3 paper.
  https://raw.githubusercontent.com/aqlaboratory/openfold-3/HEAD/README.md (2026-11-13)
- OpenBind-0 was trained on PDB data through June 2025 (cutoff 30 June 2025).
  > OB0 is trained on data from the Protein Data Bank (PDB) through June 2025
  https://openbind.uk/news/blog-openbind-0-advancing-open-molecular-structure-prediction/ (2026-11-13)
- Full training data for reproducing OpenFold3-preview are provided, including a reproduction of the MGnify-based 13M-sequence distillation set described in the AF3 paper.
  > including our reproduction of the MGnify-based 13M-sequence distillation dataset described in the AlphaFold3 paper.
  https://github.com/aqlaboratory/openfold-3/blob/main/README.md (2026-11-13)

## How to run

- On application: https://huggingface.co/OpenFold/OpenFold3
- Hosted API: https://docs.api.nvidia.com/nim/reference/openfold-openfold3

## Versions

- 0.4.2: code Apache-2.0, weights Apache-2.0

## No sourced statement yet

Limits on outputs, Overlap with benchmarks, Known defects and misuse

https://mdexa.com/models/openfold3/

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