{
  "schema_version": "2.0",
  "record_type": "dataset",
  "tier": "verified",
  "slug": "reactome",
  "name": "Reactome",
  "summary": {
    "en": "License: permissive (CC0-1.0); Mdexa hosting: link-only. Second pass: license_status: looser by the source's own words (looser-explicit): 【标准许可误作自定义条款】许可协议第1条c款写明全部数据及其派生文件采用 CC0，可复制、修改、分发，甚至用于商业，无需许可；插图等为 CC BY 4.0；软件为 Apache 2.0。唯一的\"特别许可\"针对 FoamTree 软件的本地安装，属配套软件（第21条），不参与数据状态。\"不同意即不得使用\"是接受条款，不是甲类限制。数据部分没有甲类句，按原文应为 permissive（标识 CC0-1.0），插图部分 CC BY 4.0 带 attribution；比拟定更宽，原文明示，交采纳环节放宽。 | commercial_use: looser by the source's own words (looser-explicit): 原文明示数据\"even for commercial purposes\"可用，按原文应为 yes。 | derivatives: looser by the source's own words (looser-explicit): 原文明示可修改（modify），按原文应为 yes。 | redistribution: looser by the source's own words (looser-explicit): 原文明示可分发（distribute），按原文应为",
    "zh": "许可证声明：宽松（CC0-1.0）；本站处理：只链接原出处。第二遍复核：license_status: looser by the source's own words (looser-explicit): 【标准许可误作自定义条款】许可协议第1条c款写明全部数据及其派生文件采用 CC0，可复制、修改、分发，甚至用于商业，无需许可；插图等为 CC BY 4.0；软件为 Apache 2.0。唯一的\"特别许可\"针对 FoamTree 软件的本地安装，属配套软件（第21条），不参与数据状态。\"不同意即不得使用\"是接受条款，不是甲类限制。数据部分没有甲类句，按原文应为 permissive（标识 CC0-1.0），插图部分 CC BY 4.0 带 attribution；比拟定更宽，原文明示，交采纳环节放宽。；commercial_use: looser by the source's own words (looser-explicit): 原文明示数据\"even for commercial purposes\"可用，按原文应为 yes。；derivatives: looser by the source's own words (looser-explicit): 原文明示可修改（modify），按原文应为 yes。；redistribution: looser by the source's own words (looser-explicit): 原文明示可分发（distribute），按原文应为 yes。。"
  },
  "systems": [
    "modern-medicine"
  ],
  "domains": [
    "genomics-omics"
  ],
  "content_types": [
    "database"
  ],
  "content_description": {
    "en": "The Reactome database and its contents, including all data, graphics, software, and other materials associated therewith.",
    "zh": "Reactome数据库及其内容，包括相关全部数据、图形、软件和其他材料。"
  },
  "languages": [
    "en"
  ],
  "modalities": [
    "text"
  ],
  "size": {
    "raw": null,
    "measures": []
  },
  "publisher": "Reactome",
  "year": {
    "value": null,
    "raw": null
  },
  "license": {
    "legacy_status": "pending",
    "spdx": "CC0-1.0",
    "commercial_use": "yes",
    "derivatives": "yes",
    "redistribution": "yes",
    "rationale": {
      "en": "all parts permissive; conditions are the union of the parts",
      "zh": "各部分均宽松，条件取各部分的并集"
    },
    "evidence": [
      {
        "location": "terms-page",
        "location_detail": {
          "en": "Statement found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到的声明"
        },
        "excerpt": "This License Agreement (the “Agreement”) governs the use of the Reactome database and its contents, including all data, graphics, software, and other materials associated therewith.",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "terms-page",
        "location_detail": {
          "en": "Statement found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到的声明"
        },
        "excerpt": "If you do not agree with the terms of this Agreement, you may not use Reactome.",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "terms-page",
        "location_detail": {
          "en": "Statement found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到的声明"
        },
        "excerpt": "User agrees that the content on Reactome is governed by various open-source licenses and agrees to adhere to applicable license terms as follows:",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "terms-page",
        "location_detail": {
          "en": "Statement found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到的声明"
        },
        "excerpt": "This Reactome content is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0)",
        "spdx": "CC-BY-4.0",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "terms-page",
        "location_detail": {
          "en": "Statement found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到的声明"
        },
        "excerpt": "User may copy, modify, and distribute these materials, provided that appropriate credit is given, a link to the license is included, and any modifications made by User are clearly indicated.",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "terms-page",
        "location_detail": {
          "en": "Statement found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到的声明"
        },
        "excerpt": "all Reactome software is licensed under the Apache License 2.0",
        "spdx": "Apache-2.0",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "terms-page",
        "location_detail": {
          "en": "Statement found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到的声明"
        },
        "excerpt": "Individual repositories are marked with the appropriate licensing requirements, and User must ensure their intended use is compliant with the relevant license, as applicable.",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "terms-page",
        "location_detail": {
          "en": "Statement found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到的声明"
        },
        "excerpt": "All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0)",
        "spdx": "CC0-1.0",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "terms-page",
        "location_detail": {
          "en": "Statement found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到的声明"
        },
        "excerpt": "User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission.",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "terms-page",
        "location_detail": {
          "en": "Statement found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到的声明"
        },
        "excerpt": "Attribution is encouraged but not required.",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "terms-page",
        "location_detail": {
          "en": "Statement found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到的声明"
        },
        "excerpt": "Notwithstanding the Applicable Open-Source Licenses set out in Section 1 above, User agrees to the application of Special Licenses to certain Reactome content as follows:",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "terms-page",
        "location_detail": {
          "en": "Statement found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到的声明"
        },
        "excerpt": "The FoamTree software, used to construct the ReacFoam genome-wide pathway overview, is provided under license by Carrot Search, Inc.",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "terms-page",
        "location_detail": {
          "en": "Statement found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到的声明"
        },
        "excerpt": "Images and analyses generated on the Reactome website using FoamTree software are free to use with no restriction.",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "terms-page",
        "location_detail": {
          "en": "Statement found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到的声明"
        },
        "excerpt": "For local installations of the Reactome, User must either: i) use the free, fully functional demo version of the FoamTree software included with Reactome, which adds a promotional logo to one of the cells of the visualization; or ii) obtain their own license from Carrot Search directly.",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "terms-page",
        "location_detail": {
          "en": "Statement found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到的声明"
        },
        "excerpt": "Reactome is provided “as is” and “as available” without any warranties of any kind, either express or implied.",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "terms-page",
        "location_detail": {
          "en": "Statement found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到的声明"
        },
        "excerpt": "Users must comply with all applicable licensing requirements and ensure that their access and/or use of Reactome content is consistent with the terms of this Agreement.",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "terms-page",
        "location_detail": {
          "en": "Statement found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到的声明"
        },
        "excerpt": "© 2026",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "terms-page",
        "location_detail": {
          "en": "Statement found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到的声明"
        },
        "excerpt": "This Reactome content is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0) .",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "dataset-page",
        "location_detail": {
          "en": "Part \"Data\" found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到：Part \"Data\""
        },
        "excerpt": "c) Data : All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0) .",
        "spdx": "CC0-1.0",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      },
      {
        "location": "dataset-page",
        "location_detail": {
          "en": "Part \"Pathway Illustrations, Icon Library, Art\" found in snapshot s02 (page)",
          "zh": "在快照 s02（page）中找到：Part \"Pathway Illustrations, Icon Library, Art\""
        },
        "excerpt": "a) Pathway Illustrations, Icon Library, Art, and Branding Materials . This Reactome content is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0) .",
        "spdx": "CC-BY-4.0",
        "url": "https://reactome.org/license",
        "verified_on": "2026-11-13",
        "snapshot_id": "s02",
        "observed": "page",
        "captured_by": "pipeline"
      }
    ],
    "license_conditions": [
      "attribution",
      "notice-required"
    ],
    "license_parts": [
      {
        "name": {
          "en": "Pathway Illustrations, Icon Library, Art, and Branding Materials",
          "zh": "Pathway Illustrations, Icon Library, Art, and Branding Materials"
        },
        "spdx": "CC-BY-4.0",
        "status": "permissive",
        "separable": true,
        "license_conditions": [
          "attribution"
        ],
        "evidence": {
          "excerpt": "This Reactome content is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0)",
          "url": "https://reactome.org/license",
          "snapshot_id": "s02"
        }
      },
      {
        "name": {
          "en": "Software and Code",
          "zh": "Software and Code"
        },
        "spdx": "Apache-2.0",
        "status": "permissive",
        "separable": true,
        "license_conditions": [
          "notice-required"
        ],
        "evidence": {
          "excerpt": "all Reactome software is licensed under the Apache License 2.0",
          "url": "https://reactome.org/license",
          "snapshot_id": "s02"
        }
      },
      {
        "name": {
          "en": "Data",
          "zh": "Data"
        },
        "spdx": "CC0-1.0",
        "status": "permissive",
        "separable": true,
        "evidence": {
          "excerpt": "All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0)",
          "url": "https://reactome.org/license",
          "snapshot_id": "s02"
        }
      },
      {
        "name": {
          "en": "This Reactome",
          "zh": "This Reactome"
        },
        "spdx": "CC-BY-4.0",
        "status": "permissive",
        "separable": true,
        "license_conditions": [
          "attribution"
        ],
        "evidence": {
          "excerpt": "This Reactome content is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0) .",
          "url": "https://reactome.org/license",
          "snapshot_id": "s02"
        }
      },
      {
        "name": {
          "en": "FoamTree (Voronoi Treemaps)",
          "zh": "FoamTree (Voronoi Treemaps)"
        },
        "spdx": "NOASSERTION",
        "status": "permissive",
        "separable": true,
        "evidence": {
          "excerpt": "The FoamTree software, used to construct the ReacFoam genome-wide pathway overview, is provided under license by Carrot Search, Inc.",
          "url": "https://reactome.org/license",
          "snapshot_id": "s02"
        }
      }
    ],
    "notes": {
      "en": "pointer to full license text not read: If you do not agree with the terms of this Agreement, you may not use Reactome.",
      "zh": "pointer to full license text not read: If you do not agree with the terms of this Agreement, you may not use Reactome."
    },
    "review": {
      "method": "rules-plus-second-pass-model",
      "method_label": {
        "en": "Judged by public rules and checked a second time before listing.",
        "zh": "按公开规则判定，经二次核对后收录。"
      },
      "readings": [
        {
          "restatement": {
            "en": "all parts permissive; conditions are the union of the parts",
            "zh": "各部分均宽松，条件取各部分的并集"
          },
          "quotes": [
            {
              "excerpt": "This License Agreement (the “Agreement”) governs the use of the Reactome database and its contents, including all data, graphics, software, and other materials associated therewith.",
              "snapshot_id": "s02",
              "url": "https://reactome.org/license"
            },
            {
              "excerpt": "If you do not agree with the terms of this Agreement, you may not use Reactome.",
              "snapshot_id": "s02",
              "url": "https://reactome.org/license"
            },
            {
              "excerpt": "User agrees that the content on Reactome is governed by various open-source licenses and agrees to adhere to applicable license terms as follows:",
              "snapshot_id": "s02",
              "url": "https://reactome.org/license"
            },
            {
              "excerpt": "This Reactome content is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0)",
              "snapshot_id": "s02",
              "url": "https://reactome.org/license"
            }
          ],
          "values": {
            "license_status": "permissive",
            "commercial_use": "yes",
            "derivatives": "yes",
            "redistribution": "yes"
          },
          "source": "rules"
        },
        {
          "restatement": {
            "en": "Second pass: license_status: looser by the source's own words (looser-explicit): 【标准许可误作自定义条款】许可协议第1条c款写明全部数据及其派生文件采用 CC0，可复制、修改、分发，甚至用于商业，无需许可；插图等为 CC BY 4.0；软件为 Apache 2.0。唯一的\"特别许可\"针对 FoamTree 软件的本地安装，属配套软件（第21条），不参与数据状态。\"不同意即不得使用\"是接受条款，不是甲类限制。数据部分没有甲类句，按原文应为 permissive（标识 CC0-1.0），插图部分 CC BY 4.0 带 attribution；比拟定更宽，原文明示，交采纳环节放宽。 | commercial_use: looser by the source's own words (looser-explicit): 原文明示数据\"even for commercial purposes\"可用，按原文应为 yes。 | derivatives: looser by the source's own words (looser-explicit): 原文明示可修改（modify），按原文应为 yes。 | redistribution: looser by the source's own words (looser-explicit): 原文明示可分发（distribute），按原文应为 yes。",
            "zh": "第二遍复核：license_status: looser by the source's own words (looser-explicit): 【标准许可误作自定义条款】许可协议第1条c款写明全部数据及其派生文件采用 CC0，可复制、修改、分发，甚至用于商业，无需许可；插图等为 CC BY 4.0；软件为 Apache 2.0。唯一的\"特别许可\"针对 FoamTree 软件的本地安装，属配套软件（第21条），不参与数据状态。\"不同意即不得使用\"是接受条款，不是甲类限制。数据部分没有甲类句，按原文应为 permissive（标识 CC0-1.0），插图部分 CC BY 4.0 带 attribution；比拟定更宽，原文明示，交采纳环节放宽。；commercial_use: looser by the source's own words (looser-explicit): 原文明示数据\"even for commercial purposes\"可用，按原文应为 yes。；derivatives: looser by the source's own words (looser-explicit): 原文明示可修改（modify），按原文应为 yes。；redistribution: looser by the source's own words (looser-explicit): 原文明示可分发（distribute），按原文应为 yes。"
          },
          "quotes": [
            {
              "excerpt": "All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0) .",
              "snapshot_id": "s02",
              "url": null
            },
            {
              "excerpt": "User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission.",
              "snapshot_id": "s02",
              "url": null
            },
            {
              "excerpt": "Images and analyses generated on the Reactome website using FoamTree software are free to use with no restriction.",
              "snapshot_id": "s02",
              "url": null
            },
            {
              "excerpt": "User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission.",
              "snapshot_id": "s02",
              "url": null
            }
          ],
          "values": {
            "license_status": "permissive",
            "commercial_use": "yes",
            "derivatives": "yes",
            "redistribution": "yes"
          },
          "source": "second-pass"
        }
      ],
      "adopted": 0,
      "second_pass": {
        "reviewer": "model-second-pass",
        "reviewed_at": "2026-11-14",
        "overall": "looser-explicit",
        "agreed": false,
        "disagreement": {
          "en": "Second pass: license_status: looser by the source's own words (looser-explicit): 【标准许可误作自定义条款】许可协议第1条c款写明全部数据及其派生文件采用 CC0，可复制、修改、分发，甚至用于商业，无需许可；插图等为 CC BY 4.0；软件为 Apache 2.0。唯一的\"特别许可\"针对 FoamTree 软件的本地安装，属配套软件（第21条），不参与数据状态。\"不同意即不得使用\"是接受条款，不是甲类限制。数据部分没有甲类句，按原文应为 permissive（标识 CC0-1.0），插图部分 CC BY 4.0 带 attribution；比拟定更宽，原文明示，交采纳环节放宽。 | commercial_use: looser by the source's own words (looser-explicit): 原文明示数据\"even for commercial purposes\"可用，按原文应为 yes。 | derivatives: looser by the source's own words (looser-explicit): 原文明示可修改（modify），按原文应为 yes。 | redistribution: looser by the source's own words (looser-explicit): 原文明示可分发（distribute），按原文应为 yes。",
          "zh": "第二遍复核：license_status: looser by the source's own words (looser-explicit): 【标准许可误作自定义条款】许可协议第1条c款写明全部数据及其派生文件采用 CC0，可复制、修改、分发，甚至用于商业，无需许可；插图等为 CC BY 4.0；软件为 Apache 2.0。唯一的\"特别许可\"针对 FoamTree 软件的本地安装，属配套软件（第21条），不参与数据状态。\"不同意即不得使用\"是接受条款，不是甲类限制。数据部分没有甲类句，按原文应为 permissive（标识 CC0-1.0），插图部分 CC BY 4.0 带 attribution；比拟定更宽，原文明示，交采纳环节放宽。；commercial_use: looser by the source's own words (looser-explicit): 原文明示数据\"even for commercial purposes\"可用，按原文应为 yes。；derivatives: looser by the source's own words (looser-explicit): 原文明示可修改（modify），按原文应为 yes。；redistribution: looser by the source's own words (looser-explicit): 原文明示可分发（distribute），按原文应为 yes。"
        },
        "missed_restrictions": [],
        "routing": []
      }
    }
  },
  "license_status": "permissive",
  "hosting": "link-only",
  "hosting_reason": {
    "en": "License permissive, judged by public rules and checked by a second-pass model. Link only.",
    "zh": "许可证状态：permissive，按公开规则判定并经第二遍模型复核。仅链接。"
  },
  "signoff": null,
  "risk_flags": [],
  "provenance": {
    "source_description": null,
    "upstream": []
  },
  "known_issues": [],
  "usage_notes": [
    {
      "kind": "disclaimer",
      "excerpt": "Reactome is provided “as is” and “as available” without any warranties of any kind, either express or implied.",
      "url": "https://reactome.org/license",
      "snapshot_id": "s02"
    }
  ],
  "preflight": {
    "status": "not-run"
  },
  "access": {
    "mdexa_download": null,
    "external_urls": [
      "https://reactome.org/",
      "https://reactome.org/license"
    ],
    "notes": null
  },
  "citation": {
    "text": null,
    "references": []
  },
  "verification_level": "verified",
  "last_verified": "2026-11-14",
  "tags": [
    {
      "facet": "source_type",
      "value": "knowledge-base",
      "basis": "inferred",
      "inferred_from": "card-content-description",
      "excerpt": "the Reactome database and its contents",
      "snapshot_id": "s02"
    }
  ],
  "changelog": [
    {
      "date": "2026-11-14",
      "change": {
        "en": "Listed on 2026-11-14. Judged by public rules and checked a second time before listing. The two passes disagreed; the stricter reading is carried: Second pass: license_status: looser by the source's own words (looser-explicit): 【标准许可误作自定义条款】许可协议第1条c款写明全部数据及其派生文件采用 CC0，可复制、修改、分发，甚至用于商业，无需许可；插图等为 CC BY 4.0；软件为 Apache 2.0。唯一的\"特别许可\"针对 FoamTree 软件的本地安装，属配套软件（第21条），不参与数据状态。\"不同意即不得使用\"是接受条款，不是甲类限制。数据部分没有甲类句，按原文应为 permissive（标识 CC0-1.0），插图部分 CC BY 4.0 带 attribution；比拟定更宽，原文明示，交采纳环节放宽。 | commercial_use: looser by the source's own words (looser-explicit): 原文明示数据\"even for commercial purposes\"可用，按原文应为 yes。 | derivatives: looser by the source's own words (looser-explicit): 原文明示可修改（modify），按原文应为 yes。 | redistribution: looser by the source's own words (looser-explicit): 原文明示可分发（distribute），按原文应为 yes。",
        "zh": "2026-11-14 上架。按公开规则判定，经二次核对后收录。两遍判定不一致，卡上取较严的读法：第二遍复核：license_status: looser by the source's own words (looser-explicit): 【标准许可误作自定义条款】许可协议第1条c款写明全部数据及其派生文件采用 CC0，可复制、修改、分发，甚至用于商业，无需许可；插图等为 CC BY 4.0；软件为 Apache 2.0。唯一的\"特别许可\"针对 FoamTree 软件的本地安装，属配套软件（第21条），不参与数据状态。\"不同意即不得使用\"是接受条款，不是甲类限制。数据部分没有甲类句，按原文应为 permissive（标识 CC0-1.0），插图部分 CC BY 4.0 带 attribution；比拟定更宽，原文明示，交采纳环节放宽。；commercial_use: looser by the source's own words (looser-explicit): 原文明示数据\"even for commercial purposes\"可用，按原文应为 yes。；derivatives: looser by the source's own words (looser-explicit): 原文明示可修改（modify），按原文应为 yes。；redistribution: looser by the source's own words (looser-explicit): 原文明示可分发（distribute），按原文应为 yes。"
      }
    }
  ],
  "practical": {
    "content_scope": {
      "entities": [
        {
          "kind": "human reactions, pathways, proteins, complexes, small molecules, and drugs",
          "count": 16503,
          "count_as_of": null,
          "statement": {
            "text": {
              "en": "The page states that Reactome comprises 16,503 human reactions organized into 2,889 pathways involving 32,565 proteins and modified forms of proteins encoded by 11,496 different human genes, 16,325 complexes, 2,178 small molecules, and 1,103 drugs.",
              "zh": "页面说明 Reactome 包含 16,503 个人类反应，组织为 2,889 条通路，涉及由 11,496 个不同人类基因编码的 32,565 个蛋白质及蛋白质修饰形式、16,325 个复合物、2,178 个小分子和 1,103 种药物。"
            },
            "evidence": [
              {
                "location": "dataset-page",
                "excerpt": "Reactome comprises 16,503 human reactions organized into 2,889 pathways involving 32,565 proteins and modified forms of proteins encoded by 11,496 different human genes, 16,325 complexes, 2,178 small molecules, and 1,103 drugs.",
                "url": "https://reactome.org/about/news",
                "snapshot_id": "s03",
                "char_start": 4173,
                "verified_on": "2026-11-13",
                "observed": "page",
                "captured_by": "pipeline"
              }
            ]
          }
        }
      ],
      "coverage": [
        {
          "text": {
            "en": "The page states that these reactions were projected onto 83,732 orthologous proteins, creating 20,751 orthologous pathways in 14 non-human species.",
            "zh": "页面说明这些反应被投射到 83,732 个直系同源蛋白质上，在 14 个非人类物种中创建了 20,751 条直系同源通路。"
          },
          "evidence": [
            {
              "location": "dataset-page",
              "excerpt": "We have projected these reactions onto 83,732 orthologous proteins, creating 20,751 orthologous pathways in 14 non-human species.",
              "url": "https://reactome.org/about/news",
              "snapshot_id": "s03",
              "char_start": 4466,
              "verified_on": "2026-11-13",
              "observed": "page",
              "captured_by": "pipeline"
            }
          ]
        }
      ]
    },
    "identifiers": {
      "schemes": [
        {
          "name": "stable identifiers",
          "bioregistry_prefix": null,
          "applies_to": "the Reactome database",
          "statement": {
            "text": {
              "en": "The download page lists a stable identifiers database.",
              "zh": "下载页面列出了稳定标识符数据库。"
            },
            "evidence": [
              {
                "location": "dataset-page",
                "excerpt": "Stable identifiers database",
                "url": "https://reactome.org/download-data",
                "snapshot_id": "s04",
                "char_start": 3740,
                "verified_on": "2026-11-13",
                "observed": "page",
                "captured_by": "pipeline"
              }
            ]
          }
        }
      ],
      "crosswalks": [
        {
          "to": "UniProt",
          "to_slug": null,
          "statement": {
            "text": {
              "en": "The page lists the entry UniProt to pathways.",
              "zh": "页面列出了一个条目：UniProt to pathways。"
            },
            "evidence": [
              {
                "location": "dataset-page",
                "excerpt": "UniProt to pathways",
                "url": "https://reactome.org/download-data",
                "snapshot_id": "s04",
                "char_start": 4107,
                "verified_on": "2026-11-13",
                "observed": "page",
                "captured_by": "pipeline"
              }
            ]
          }
        },
        {
          "to": "ChEBI",
          "to_slug": null,
          "statement": {
            "text": {
              "en": "The page lists the entry ChEBI to pathways.",
              "zh": "页面列出了一个条目：ChEBI to pathways。"
            },
            "evidence": [
              {
                "location": "dataset-page",
                "excerpt": "ChEBI to pathways",
                "url": "https://reactome.org/download-data",
                "snapshot_id": "s04",
                "char_start": 4129,
                "verified_on": "2026-11-13",
                "observed": "page",
                "captured_by": "pipeline"
              }
            ]
          }
        },
        {
          "to": "ENSEMBL",
          "to_slug": null,
          "statement": {
            "text": {
              "en": "The page lists the entry ENSEMBL to pathways.",
              "zh": "页面列出了一个条目：ENSEMBL to pathways。"
            },
            "evidence": [
              {
                "location": "dataset-page",
                "excerpt": "ENSEMBL to pathways",
                "url": "https://reactome.org/download-data",
                "snapshot_id": "s04",
                "char_start": 4149,
                "verified_on": "2026-11-13",
                "observed": "page",
                "captured_by": "pipeline"
              }
            ]
          }
        },
        {
          "to": "miRBase",
          "to_slug": null,
          "statement": {
            "text": {
              "en": "The page lists the entry miRBase to pathways.",
              "zh": "页面列出了一个条目：miRBase to pathways。"
            },
            "evidence": [
              {
                "location": "dataset-page",
                "excerpt": "miRBase to pathways",
                "url": "https://reactome.org/download-data",
                "snapshot_id": "s04",
                "char_start": 4171,
                "verified_on": "2026-11-13",
                "observed": "page",
                "captured_by": "pipeline"
              }
            ]
          }
        },
        {
          "to": "NCBI",
          "to_slug": null,
          "statement": {
            "text": {
              "en": "The page lists the entry NCBI to pathways.",
              "zh": "页面列出了一个条目：NCBI to pathways。"
            },
            "evidence": [
              {
                "location": "dataset-page",
                "excerpt": "NCBI to pathways",
                "url": "https://reactome.org/download-data",
                "snapshot_id": "s04",
                "char_start": 4193,
                "verified_on": "2026-11-13",
                "observed": "page",
                "captured_by": "pipeline"
              }
            ]
          }
        },
        {
          "to": "GtoP",
          "to_slug": null,
          "statement": {
            "text": {
              "en": "The page lists the entry GtoP to pathways.",
              "zh": "页面列出了一个条目：GtoP to pathways。"
            },
            "evidence": [
              {
                "location": "dataset-page",
                "excerpt": "GtoP to pathways",
                "url": "https://reactome.org/download-data",
                "snapshot_id": "s04",
                "char_start": 4212,
                "verified_on": "2026-11-13",
                "observed": "page",
                "captured_by": "pipeline"
              }
            ]
          }
        },
        {
          "to": "OMIM",
          "to_slug": null,
          "statement": {
            "text": {
              "en": "The page lists the entry Reactome to OMIM.",
              "zh": "页面列出了一个条目：Reactome to OMIM。"
            },
            "evidence": [
              {
                "location": "dataset-page",
                "excerpt": "Reactome to OMIM",
                "url": "https://reactome.org/download-data",
                "snapshot_id": "s04",
                "char_start": 5459,
                "verified_on": "2026-11-13",
                "observed": "page",
                "captured_by": "pipeline"
              }
            ]
          }
        },
        {
          "to": "BioModels",
          "to_slug": null,
          "statement": {
            "text": {
              "en": "The page lists the entry BioModels to Pathways.",
              "zh": "页面列出了一个条目：BioModels to Pathways。"
            },
            "evidence": [
              {
                "location": "dataset-page",
                "excerpt": "BioModels to Pathways",
                "url": "https://reactome.org/download-data",
                "snapshot_id": "s04",
                "char_start": 5418,
                "verified_on": "2026-11-13",
                "observed": "page",
                "captured_by": "pipeline"
              }
            ]
          }
        }
      ],
      "mismatch_cases": [],
      "notes": [
        {
          "text": {
            "en": "Pathways and events carry stable identifiers with a species prefix, e.g. R-HSA-9006925 for a human pathway.",
            "zh": "通路与事件使用带物种前缀的稳定标识符，如人类通路 R-HSA-9006925。"
          },
          "evidence": [
            {
              "location": "peer-reviewed-paper",
              "excerpt": "The pathway, ‘Intracellular signaling by second messengers ( R-HSA-9006925 )’ (A) includes a subpathway, ‘AKT phosphorylates targets in the nucleus ( R-HSA-198693 )’ (B) that shows normally regulated signaling mediated by AKT.",
              "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10767911/",
              "snapshot_id": "s06",
              "char_start": 19229,
              "verified_on": "2026-11-14",
              "observed": "page",
              "source_work": {
                "title": "The Reactome Pathway Knowledgebase 2024",
                "authors_or_org": "Milacic M, Beavers D, Conley P, et al. (Nucleic Acids Research)",
                "date": "2024-01-01",
                "date_as_written": "2024-01-01",
                "source_type": "peer-reviewed-paper",
                "open_access": true,
                "doi_or_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10767911/"
              }
            }
          ]
        }
      ]
    },
    "access_methods": [
      {
        "method": "web-ui-only",
        "url": "https://reactome.org/about/news",
        "formats": [],
        "limits": [],
        "terms": {
          "same_as_card_license": true,
          "own_terms": null
        },
        "reachable": {
          "status": 200,
          "checked_on": "2026-11-14"
        }
      },
      {
        "method": "bulk-download",
        "url": "https://reactome.org/download-data",
        "formats": [
          "BioPAX",
          "PSI-MITAB",
          "SBML",
          "SBGN"
        ],
        "limits": [],
        "terms": {
          "same_as_card_license": true,
          "own_terms": null
        },
        "reachable": {
          "status": 200,
          "checked_on": "2026-11-14"
        }
      },
      {
        "method": "database-dump",
        "url": "https://reactome.org/download-data",
        "formats": [],
        "limits": [],
        "terms": {
          "same_as_card_license": true,
          "own_terms": null
        },
        "reachable": {
          "status": 200,
          "checked_on": "2026-11-14"
        }
      },
      {
        "method": "web-ui-only",
        "url": "https://reactome.org/license",
        "formats": [],
        "limits": [],
        "terms": {
          "same_as_card_license": true,
          "own_terms": null
        },
        "statement": {
          "text": {
            "en": "All Reactome data and files derived from it are under CC0, usable commercially without permission.",
            "zh": "Reactome 全部数据及其衍生文件采用 CC0，可商用且无需许可。"
          },
          "evidence": [
            {
              "location": "dataset-page",
              "excerpt": "c) Data : All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0) .",
              "url": "https://reactome.org/license",
              "snapshot_id": "s07",
              "char_start": null,
              "verified_on": "2026-11-14",
              "observed": "page",
              "source_work": {
                "title": "Reactome License Agreement",
                "authors_or_org": "Reactome (OICR, EMBL-EBI, NYU Langone, OHSU)",
                "date": null,
                "date_as_written": null,
                "source_type": "official-page",
                "open_access": true,
                "doi_or_url": "https://reactome.org/license"
              }
            }
          ]
        },
        "reachable": {
          "status": 200,
          "checked_on": "2026-11-14"
        }
      }
    ],
    "versioning": {
      "latest": null,
      "update_cycle": {
        "cycle": "quarterly",
        "statement": {
          "text": {
            "en": "The page states that the Zenodo download directory is created for every Reactome release quarterly, starting from version 89 (06/2024), and contains download files.",
            "zh": "页面说明 Zenodo 下载目录针对每个 Reactome 版本按季度创建，从版本 89（06/2024）开始，包含下载文件。"
          },
          "evidence": [
            {
              "location": "dataset-page",
              "excerpt": "The Zenodo download directory is created for every Reactome (reactome.org) release quarterly, starting from version 89 (06/2024), containing download files.",
              "url": "https://reactome.org/download-data",
              "snapshot_id": "s04",
              "char_start": 3153,
              "verified_on": "2026-11-13",
              "observed": "page",
              "captured_by": "pipeline"
            }
          ]
        }
      },
      "breaking_changes": [
        {
          "version": "V94",
          "date": null,
          "kind": "format",
          "statement": {
            "text": {
              "en": "The page notes that, as of Reactome V94, the Events in BioPAX level 2 format will no longer be available.",
              "zh": "页面指出，自 Reactome V94 起，Events in BioPAX level 2 format 将不再提供。"
            },
            "evidence": [
              {
                "location": "dataset-page",
                "excerpt": "Note: As of Reactome V94, the “Events in BioPAX level 2 format\" will no longer be available.",
                "url": "https://reactome.org/download-data",
                "snapshot_id": "s04",
                "char_start": 6675,
                "verified_on": "2026-11-13",
                "observed": "page",
                "captured_by": "pipeline"
              }
            ]
          }
        },
        {
          "version": "V94",
          "date": null,
          "kind": "content-removed",
          "statement": {
            "text": {
              "en": "The page notes that, as of Reactome V94, the Protégé 2.0 ontology files will no longer be available.",
              "zh": "页面指出，自 Reactome V94 起，Protégé 2.0 ontology files 将不再提供。"
            },
            "evidence": [
              {
                "location": "dataset-page",
                "excerpt": "Note: As of Reactome V94, the “Protégé 2.0 ontology files” will no longer be available.",
                "url": "https://reactome.org/download-data",
                "snapshot_id": "s04",
                "char_start": 7024,
                "verified_on": "2026-11-13",
                "observed": "page",
                "captured_by": "pipeline"
              }
            ]
          }
        }
      ],
      "history_url": null,
      "notes": [
        {
          "text": {
            "en": "Reactome uses numbered releases; the news page records V98 as released on 21 October 2026.",
            "zh": "Reactome 采用编号版本；新闻页记录 V98 于 2026-10-21 发布。"
          },
          "evidence": [
            {
              "location": "official-release-notes",
              "excerpt": "V98 Released",
              "url": "https://reactome.org/about/news",
              "snapshot_id": "s05",
              "char_start": 3307,
              "verified_on": "2026-11-14",
              "observed": "page",
              "source_work": {
                "title": "Reactome News — V98 Released",
                "authors_or_org": "Reactome (OICR, EMBL-EBI, NYU Langone, OHSU)",
                "date": "2026-10-21",
                "date_as_written": "2026-10-21",
                "source_type": "official-release-notes",
                "open_access": true,
                "doi_or_url": "https://reactome.org/about/news"
              }
            }
          ]
        }
      ]
    },
    "known_defects": [
      {
        "kind": "data-quality",
        "statement": {
          "text": {
            "en": "The page states that interactions are inferred between all protein components of a complex and that, to limit the creation of false-positive inferences, only complexes with four or fewer protein components are considered.",
            "zh": "页面说明，复合物的所有蛋白质组分之间都会推断相互作用；为限制假阳性推断的产成，仅考虑蛋白质组分不超过四个的复合物。"
          },
          "evidence": [
            {
              "location": "dataset-page",
              "excerpt": "Interactions are inferred between all protein components of a complex. To limit the creation of false-positive inferences, only complexes with four or fewer protein components are considered.",
              "url": "https://reactome.org/download-data",
              "snapshot_id": "s04",
              "char_start": 7416,
              "verified_on": "2026-11-13",
              "observed": "page",
              "captured_by": "pipeline"
            }
          ]
        },
        "source_kind": "official-note",
        "scope": "interactions between protein components of a complex",
        "attribution": {
          "who": "reactome.org",
          "when": "2026-11-13",
          "source_type": "official-page",
          "title": null
        },
        "correction_entrance": "Report an error through the publisher: https://reactome.org/"
      }
    ],
    "fit": {
      "suited_for": [
        {
          "text": {
            "en": "The page states that the services and software tools are designed for biologists, bioinformaticians, and software developers.",
            "zh": "页面说明这些服务和软件工具面向生物学家、生物信息学家和软件开发人员设计。"
          },
          "evidence": [
            {
              "location": "dataset-page",
              "excerpt": "Our services and software tools are designed for biologists, bioinformaticians, and software developers.",
              "url": "https://reactome.org/about/news",
              "snapshot_id": "s03",
              "char_start": 4878,
              "verified_on": "2026-11-13",
              "observed": "page",
              "captured_by": "pipeline"
            }
          ]
        },
        {
          "text": {
            "en": "The page states that the Reactome FIViz app and ReactomeGSA package provide tools for multi-omics data analysis.",
            "zh": "页面说明 Reactome FIViz 应用和 ReactomeGSA 软件包提供用于多组学数据分析的工具。"
          },
          "evidence": [
            {
              "location": "dataset-page",
              "excerpt": "The Reactome FIViz app and ReactomeGSA package provide tools for multi-omics data analysis.",
              "url": "https://reactome.org/about/news",
              "snapshot_id": "s03",
              "char_start": 5156,
              "verified_on": "2026-11-13",
              "observed": "page",
              "captured_by": "pipeline"
            }
          ]
        }
      ],
      "not_suited_for": []
    },
    "commercial_access": {
      "route": "unknown",
      "url": null,
      "statement": null
    },
    "completeness": {
      "core_complete": false,
      "literature_defects": 0,
      "reachable_access": 4,
      "meets_practical_bar": false,
      "gaps": [
        {
          "field": "versioning.latest",
          "note": "未找到有出处的说明 / no sourced statement found"
        },
        {
          "field": "fit.not_suited_for",
          "note": "未找到有出处的说明 / no sourced statement found"
        },
        {
          "field": "commercial_access",
          "note": "未找到有出处的说明 / no sourced statement found"
        }
      ]
    }
  },
  "access_recipe": {
    "verified_on": "2026-11-14",
    "latest_release": {
      "version": "V98",
      "date": null,
      "evidence": {
        "excerpt": "V98 Released",
        "snapshot_id": "s03",
        "url": "https://reactome.org/about/news"
      }
    },
    "files": [],
    "api": [],
    "registration": null,
    "bulk_download": [],
    "gaps": [
      "no direct file address was found on the official pages we hold",
      "the official pages we hold publish no checksum for the files; none was computed (we do not download data files)"
    ],
    "license_note": {
      "license_status": "permissive",
      "text": "Use according to the terms of the official source; this recipe does not say the data can be used freely."
    }
  },
  "_links": {
    "text": "在本库继续查找。本条目是 109 条已处理并核实的记录之一（数据集、数据资源与开源模型）。查找其他条目：调用 `https://mcp.mdexa.com/v1/datasets?q=<关键词>`，或连接 MCP 服务 `https://mcp.mdexa.com/mcp`；每分钟 20 次以内无需密钥。每行返回不到 1 KB；空结果即\"数据库未收录\"。核对一份清单：一次批量核对（免费账号）即返回报告。说明：/agents.md。相似条目：STRING (https://mdexa.com/zh/datasets/string/)；AlphaFold Protein Structure Database (https://mdexa.com/zh/datasets/alphafold-db/)；GEO (https://mdexa.com/zh/datasets/geo/)。",
    "records": 109,
    "search": {
      "template": "https://mcp.mdexa.com/v1/datasets?q={words}",
      "example": "https://mcp.mdexa.com/v1/datasets?q=%E7%BB%93%E5%90%88%E4%BA%B2%E5%92%8C%E5%8A%9B"
    },
    "mcp": "https://mcp.mdexa.com/mcp",
    "anonymous_calls_per_minute": 20,
    "guide": "https://mdexa.com/zh/agents.md",
    "faq": "https://mdexa.com/zh/developers/faq/",
    "similar": [
      {
        "name": "STRING",
        "url": "https://mdexa.com/zh/datasets/string/",
        "json": "https://mdexa.com/zh/datasets/string.json"
      },
      {
        "name": "AlphaFold Protein Structure Database",
        "url": "https://mdexa.com/zh/datasets/alphafold-db/",
        "json": "https://mdexa.com/zh/datasets/alphafold-db.json"
      },
      {
        "name": "GEO",
        "url": "https://mdexa.com/zh/datasets/geo/",
        "json": "https://mdexa.com/zh/datasets/geo.json"
      }
    ]
  }
}