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License status and Mdexa hosting, recorded separatelyAll datasets

PubChem

Verified by Mdexa · Checked against the source text under public rules.How we check

Commercial use
Yes
Derivatives
Yes
Redistribution
Yes
File on Mdexa
NoLink only

all parts permissive

PermissiveLink onlyLicenseRef-PublicDomainSave

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Mdexa verified · Permissive · 2026-11Mdexa verifiedPermissive · 2026-11

[![Mdexa verified · Permissive · 2026-11](https://mcp.mdexa.com/v1/badge/datasets/pubchem.svg)](https://mdexa.com/datasets/pubchem/)

Place it on a repository or dataset page; the status and date follow the verification. About badges

Cite this pageMdexa, PubChem, https://mdexa.com/datasets/pubchem/, verified 2026-11-14.

Key facts

Domain
Pharmacy and drugs Modern medicine
Content
Databases
Size
—
Language / modality
English / Text
Publisher
U.S. National Library of Medicine (NCBI)
Year
—
Expert review
—
Verification
Partially verified

Commercial use of PubChem

Commercial use: Yes. The overall verdict takes the strictest part; the parts carry different licenses, listed below. License status: Permissive.

License part
main data — Permissive (LicenseRef-PublicDomain)
License part
PubChem — Permissive (LicenseRef-PublicDomain)

Quoted statements and their sources are in PubChem license evidence.

Verdicts record what sources state and are not legal advice.

Practical information

Content scope

  • The text refers to PubChem records as Compound Summary, Substance Record, and BioAssay Record entries.
    pubchem.ncbi.nlm.nih.gov ·
    All or part of the data for an individual PubChem record may be downloaded in various file formats, using the Download button available on the top-right corner of a Compound Summary, Substance Record, or BioAssay Record page.

    https://pubchem.ncbi.nlm.nih.gov/docs/downloads · api-doc · checked 2026-11-13

  • The text states that the data in PubChem comes from hundreds of data contributors.
    pubchem.ncbi.nlm.nih.gov ·
    The data in PubChem comes from hundreds of data contributors (https://pubchem.ncbi.nlm.nih.gov/source/).

    https://pubchem.ncbi.nlm.nih.gov/docs/downloads · api-doc · checked 2026-11-13

Access

  • Web APIpubchem.ncbi.nlm.nih.gov
    • Own terms: commercial use Not stated · redistribution Not stated
      pubchem.ncbi.nlm.nih.gov ·
      PUG-REST, a Representational State Transfer (REST)-style web service that supplies specific bits of information on one or more PubChem records, and is a good place to start for most users.

      https://pubchem.ncbi.nlm.nih.gov/docs/programmatic-access · api-doc · checked 2026-11-13

    • The usage policy asks that any user, application, or organization not make more than 5 requests per second to the PubChem web services.
      pubchem.ncbi.nlm.nih.gov ·
      USAGE POLICY: Please note that PubChem web services run on a limited pool of servers shared by all PubChem users. We ask that any user, application, or organization not make more than 5 requests per second, in order to avoid overloading these servers.

      https://pubchem.ncbi.nlm.nih.gov/docs/programmatic-access · api-doc · checked 2026-11-13

    • The page states that API keys or whitelists to exceed these limits cannot be offered.
      pubchem.ncbi.nlm.nih.gov ·
      We cannot offer API keys or whitelists to exceed these limits.

      https://pubchem.ncbi.nlm.nih.gov/docs/programmatic-access · api-doc · checked 2026-11-13

    • The NCBI page asks that no more than 3 requests be made every 1 second.
      ncbi.nlm.nih.gov ·
      Make no more than 3 requests every 1 second.

      https://www.ncbi.nlm.nih.gov/home/about/policies/ · Terms of use page · checked 2026-11-12

  • Web APIpubchem.ncbi.nlm.nih.gov
    • Own terms: commercial use Not stated · redistribution Not stated
      pubchem.ncbi.nlm.nih.gov ·
      PUG-View is a REST-style web service that provides full reports, including third-party textual annotation, for individual PubChem records.

      https://pubchem.ncbi.nlm.nih.gov/docs/programmatic-access · api-doc · checked 2026-11-13

    • The usage policy asks that any user, application, or organization not make more than 5 requests per second to the PubChem web services.
      pubchem.ncbi.nlm.nih.gov ·
      USAGE POLICY: Please note that PubChem web services run on a limited pool of servers shared by all PubChem users. We ask that any user, application, or organization not make more than 5 requests per second, in order to avoid overloading these servers.

      https://pubchem.ncbi.nlm.nih.gov/docs/programmatic-access · api-doc · checked 2026-11-13

    • The page states that API keys or whitelists to exceed these limits cannot be offered.
      pubchem.ncbi.nlm.nih.gov ·
      We cannot offer API keys or whitelists to exceed these limits.

      https://pubchem.ncbi.nlm.nih.gov/docs/programmatic-access · api-doc · checked 2026-11-13

    • The NCBI page asks that no more than 3 requests be made every 1 second.
      ncbi.nlm.nih.gov ·
      Make no more than 3 requests every 1 second.

      https://www.ncbi.nlm.nih.gov/home/about/policies/ · Terms of use page · checked 2026-11-12

  • Web APIpubchem.ncbi.nlm.nih.gov
    • Own terms: commercial use Not stated · redistribution Not stated
      pubchem.ncbi.nlm.nih.gov ·
      This is a REST-style interface designed to access RDF-encoded PubChem data. See PubChemRDF for more details.

      https://pubchem.ncbi.nlm.nih.gov/docs/programmatic-access · api-doc · checked 2026-11-13

    • The usage policy asks that any user, application, or organization not make more than 5 requests per second to the PubChem web services.
      pubchem.ncbi.nlm.nih.gov ·
      USAGE POLICY: Please note that PubChem web services run on a limited pool of servers shared by all PubChem users. We ask that any user, application, or organization not make more than 5 requests per second, in order to avoid overloading these servers.

      https://pubchem.ncbi.nlm.nih.gov/docs/programmatic-access · api-doc · checked 2026-11-13

    • The page states that API keys or whitelists to exceed these limits cannot be offered.
      pubchem.ncbi.nlm.nih.gov ·
      We cannot offer API keys or whitelists to exceed these limits.

      https://pubchem.ncbi.nlm.nih.gov/docs/programmatic-access · api-doc · checked 2026-11-13

    • The NCBI page asks that no more than 3 requests be made every 1 second.
      ncbi.nlm.nih.gov ·
      Make no more than 3 requests every 1 second.

      https://www.ncbi.nlm.nih.gov/home/about/policies/ · Terms of use page · checked 2026-11-12

  • Bulk downloadpubchem.ncbi.nlm.nih.gov

    Same terms as the card's license.

    • The page states that exceptions may exist where licensing agreements prevent data contributors from allowing bulk downloads of some data sets.
      pubchem.ncbi.nlm.nih.gov ·
      Exceptions may exist in cases where licensing agreements prevent our data contributors from allowing bulk downloads of some data sets.

      https://pubchem.ncbi.nlm.nih.gov/docs/downloads · api-doc · checked 2026-11-13

  • Web interface onlypubchem.ncbi.nlm.nih.gov

    Same terms as the card's license.

  • Web interface onlypmc.ncbi.nlm.nih.gov

    Same terms as the card's license.

  • Bulk downloadftp.ncbi.nlm.nih.gov

    Same terms as the card's license.

Known defects and misuse

  • Butkiewicz et al.: PubChem primary HTS screens contain many false-positive hits that are inactive in confirmatory assays; they built benchmark sets from confirmatory screens after manual verification.
    pmc.ncbi.nlm.nih.gov ·
    Primary screens often include many false-positive hit compounds which display a response in initial assay experiments but are inactive in confirmatory experiments.

    https://pmc.ncbi.nlm.nih.gov/articles/PMC3759399/ · peer-reviewed-paper · checked 2026-11-14

Suited for

  • The molecular databases are described as designed to provide and encourage access within the scientific community to sources of current and comprehensive information.
    ncbi.nlm.nih.gov ·
    They are designed to provide and encourage access within the scientific community to sources of current and comprehensive information.

    https://www.ncbi.nlm.nih.gov/home/about/policies/ · Terms of use page · checked 2026-11-12

Commercial licensing

  • The page states that a data source may provide explicit data license information and that one should check with the PubChem data source for the most current data licensing information.
    pubchem.ncbi.nlm.nih.gov ·
    A data source may provide explicit data license information. One should check with the PubChem data source for the most current data licensing information.

    https://pubchem.ncbi.nlm.nih.gov/docs/downloads · api-doc · checked 2026-11-13

  • Commercial licensing

PubChem license evidence 8

Conditions are the union of the parts

  1. Site policy pagePage opened
    Third-party text · Site policy pageInformation that is created by or for the US government on this site is within the public domain. Public domain information on the National Library of Medicine (NLM) Web pages may be freely distributed and copied.

    Statement found in snapshot s02 (page)

    ncbi.nlm.nih.gov2026-11-12 · s02
  2. Site policy pagePage opened
    Third-party text · Site policy pageOMIM (see OMIM Copyright Status ), and PubChem. All persons reproducing, redistributing, or making commercial use of this information are expected to adhere to the terms and conditions asserted by the copyright holder.

    Statement found in snapshot s02 (page)

    ncbi.nlm.nih.gov2026-11-12 · s02
  3. Site policy pagePage opened
    Third-party text · Site policy pageThey are designed to provide and encourage access within the scientific community to sources of current and comprehensive information. Therefore, NCBI itself places no restrictions on the use or distribution of the data contained therein.

    Statement found in snapshot s02 (page)

    ncbi.nlm.nih.gov2026-11-12 · s02
  1. Site policy pagePage opened
    Third-party text · Site policy pageNor do we accept data when the submitter has requested restrictions on reuse or redistribution.

    Statement found in snapshot s02 (page)

    ncbi.nlm.nih.gov2026-11-12 · s02
  2. Site policy pagePage opened
    Third-party text · Site policy pageHowever, some submitters of the original data (or the country of origin of such data) may claim patent, copyright, or other intellectual property rights in all or a portion of the data (that has been submitted).

    Statement found in snapshot s02 (page)

    ncbi.nlm.nih.gov2026-11-12 · s02
  3. Site policy pagePage opened
    Third-party text · Site policy pageTherefore, NCBI cannot provide comment or unrestricted permission concerning the use, copying, or distribution of the information contained in the molecular databases.

    Statement found in snapshot s02 (page)

    ncbi.nlm.nih.gov2026-11-12 · s02
  4. Site policy pagePage opened
    Third-party text · Site policy pageIt is the responsibility of the user to examine the copyright and licensing restrictions of linked pages and to secure all necessary permissions.

    Statement found in snapshot s02 (page)

    ncbi.nlm.nih.gov2026-11-12 · s02
  5. Site policy pagePage opened
    Third-party text · Site policy pageMake no more than 3 requests every 1 second.

    Statement found in snapshot s02 (page)

    ncbi.nlm.nih.gov2026-11-12 · s02

Source and lineage

No upstream or downstream datasets recorded.

Known issues with PubChem

  • NCBI states it cannot assess third-party intellectual-property claims and cannot grant unrestricted permission to use, copy, or distribute the information in its molecular databases.

Preflight

Not run Runs only on ingested data; says nothing about quality.

Downloading PubChem and API access

No file on Mdexa (see the verdict). Get it from the source and confirm the terms there:

Citing PubChem

Mdexa, PubChem, https://mdexa.com/datasets/pubchem/, verified 2026-11-14.
More citation details

The source gives no citation text; the line above cites this card.

Machine-readable

pubchem.jsonpubchem.mdcatalog.json

Change log 11
2026-11-14Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is.
2026-11-14Practical fields (scope, identifiers, access methods, versions, known defects) were added by the automated pipeline from stored page snapshots; every statement carries a verbatim quote.
2026-11-14Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is.
2026-11-14Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is.
2026-11-14Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is.
2026-11-14Re-adjudicated under the current rules; all machine checks still pass.
2026-11-14Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is.
2026-11-14Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is.
2026-11-14Re-adjudicated under the current rules; all machine checks still pass.
2026-11-14Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is.
2026-11-13Added via the automated pipeline and passed all checks (gates, verbatim quotes, rule engine, two independent extractions).

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No sourced statement yet

Latest version · Update cycle · Breaking changes · Unsuited tasks