AlphaFold 3

AlphaFold 3 代码与权重许可

AlphaFold 3 是否允许商业使用

代码

可以 · 宽松

权重

不可以 · 有限制

代码与权重的许可分别成立，一方的结论不外推到另一方。原文与出处见上方许可一节。

结论仅记录来源所述，不构成法律意见。

对输出的限制

• 不得使用输出结果训练或构建与 AlphaFold 3 类似的生物分子结构预测机器学习模型或相关技术。
  raw.githubusercontent.com · 2026-11-13

  Use Output to train or create machine learning models or related technology for biomolecular structure prediction similar to AlphaFold 3

  https://raw.githubusercontent.com/google-deepmind/alphafold3/main/WEIGHTS_PROHIBITED_USE_POLICY.md · 使用条款页 · 核实于 2026-11-13

• 模型参数及其输出仅限大学、非营利组织、研究机构、教育机构、新闻机构和政府机构等非商业组织自身或代表其进行非商业使用。
  raw.githubusercontent.com · 2026-11-13

  The AlphaFold 3 model parameters and output are **only** available for non-commercial use by, or on behalf of, non-commercial organizations (*i.e.*, universities, non-profit organizations and research institutes, educational, journalism and government bodies).

  https://raw.githubusercontent.com/google-deepmind/alphafold3/main/WEIGHTS_TERMS_OF_USE.md · 使用条款页 · 核实于 2026-11-13

• AlphaFold 3 及其输出仅用于理论建模，并非为临床用途设计、验证或批准。
  raw.githubusercontent.com · 2026-11-13

  AlphaFold 3 and its output are for theoretical modeling only. They are not intended, validated, or approved for clinical use.

  https://raw.githubusercontent.com/google-deepmind/alphafold3/HEAD/README.md · README · 核实于 2026-11-13

• 《输出使用条款》（最后修改 2024-11-09）禁止代表商业机构或在商业活动中使用 AF3 输出，包括为其开展的研究。
  github.com · 2026-11-13

  Output are made available free of charge, for non-commercial use

  https://github.com/google-deepmind/alphafold3/blob/main/OUTPUT_TERMS_OF_USE.md · 数据集页面 · 核实于 2026-11-13

• 不得用 AF3 输出训练或构建与 AF3 类似的生物分子结构预测模型，包括通过蒸馏。
  github.com · 2026-11-13

  biomolecular structure prediction similar to AlphaFold 3 as made available

  https://github.com/google-deepmind/alphafold3/blob/main/OUTPUT_TERMS_OF_USE.md · 数据集页面 · 核实于 2026-11-13

• 来源原句：You must not share Output with any commercial organization.
  raw.githubusercontent.com · 2026-11-13

  You must not share Output with any commercial organization.

  https://raw.githubusercontent.com/google-deepmind/alphafold3/main/OUTPUT_TERMS_OF_USE.md · model-card-page · 核实于 2026-11-13

• 来源原句：Distribute Output, or disclose findings arising from using AlphaFold 3 without citing our paper:
  raw.githubusercontent.com · 2026-11-13

  Distribute Output, or disclose findings arising from using AlphaFold 3 without citing our paper:

  https://raw.githubusercontent.com/google-deepmind/alphafold3/main/WEIGHTS_PROHIBITED_USE_POLICY.md · model-card-page · 核实于 2026-11-13

• 来源原句：making decisions in domains that affect material or individual rights or
  raw.githubusercontent.com · 2026-11-13

  making decisions in domains that affect material or individual rights or

  https://raw.githubusercontent.com/google-deepmind/alphafold3/main/OUTPUT_TERMS_OF_USE.md · model-card-page · 核实于 2026-11-13

训练数据

• training data 训练所用结构数据均不晚于 2021-09-30 发布。
  pmc.ncbi.nlm.nih.gov · 2026-11-13

  No structural data used during training were released after 30 September 2021

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11168924/ · peer-reviewed-paper · 核实于 2026-11-13

• training data 训练数据中加入了 AlphaFold-Multimer v2.3 的预测结构（交叉蒸馏）。
  pmc.ncbi.nlm.nih.gov · 2026-11-13

  we use a cross-distillation method in which we enrich the training data with structures predicted by AlphaFold-Multimer (v.2.3)

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11168924/ · peer-reviewed-paper · 核实于 2026-11-13

AlphaFold 3 运行方式

• 权重下载storage.googleapis.com
• 托管接口alphafoldserver.com
• 第三方托管github.com

AlphaFold 3 各版本

• unspecified（2026-06-09）：代码 —，权重 —
  github.com · 2026-11-13

  Only the code is re-licensed, the weights license and terms of use stay the same.

  https://github.com/google-deepmind/alphafold3/commit/7b197fe859 · official-change-notice · 核实于 2026-11-13

• AlphaFold 3（2026-07-23）：代码 —，权重 —
  github.com · 2026-11-13

  request access to the AlphaFold 3 model parameters, please complete

  https://github.com/google-deepmind/alphafold3/commit/dd1a7badb6 · official-change-notice · 核实于 2026-11-13

与基准的重叠

AlphaFold 3 官方下载地址

• 仓库或发布页https://github.com/google-deepmind/alphafold3
• 权重页https://raw.githubusercontent.com/google-deepmind/alphafold3/main/WEIGHTS_TERMS_OF_USE.md
• 许可文件https://raw.githubusercontent.com/google-deepmind/alphafold3/main/LICENSE
• 论文https://arxiv.org/abs/2510.24670