Get started Console

Modern medicine75

Traditional medicine24

Cross-cutting12

Collections

Models8

License status and Mdexa hosting, recorded separatelyAll datasets

Reactome

Verified by Mdexa · Checked against the source text under public rules.How we check

Commercial use
Yes
Derivatives
Yes
Redistribution
Yes
File on Mdexa
NoLink only

all parts permissive

PermissiveLink onlyCC0-1.0Save

Badge

Mdexa verified · Permissive · 2026-11Mdexa verifiedPermissive · 2026-11

[![Mdexa verified · Permissive · 2026-11](https://mcp.mdexa.com/v1/badge/datasets/reactome.svg)](https://mdexa.com/datasets/reactome/)

Place it on a repository or dataset page; the status and date follow the verification. About badges

Cite this pageMdexa, Reactome, https://mdexa.com/datasets/reactome/, verified 2026-11-14.

Key facts

Domain
Genomics and omics Modern medicine
Content
DatabasesThe Reactome database and its contents, including all data, graphics, software, and other materials associated therewith.
Size
—
Language / modality
English / Text
Publisher
Reactome
Year
—
Expert review
—
Verification
Verified: license text seen

Commercial use of Reactome

Commercial use: Yes. The overall verdict takes the strictest part; the parts carry different licenses, listed below. License status: Permissive.

Conditions
Attribution, Notice kept
License part
Pathway Illustrations, Icon Library, Art, and Branding Materials — Permissive (CC-BY-4.0)
License part
Software and Code — Permissive (Apache-2.0)
License part
Data — Permissive (CC0-1.0)
License part
This Reactome — Permissive (CC-BY-4.0)
License part
FoamTree (Voronoi Treemaps) — Permissive (NOASSERTION)

Quoted statements and their sources are in Reactome license evidence.

Verdicts record what sources state and are not legal advice.

Practical information

Content scope

  • The page states that Reactome comprises 16,503 human reactions organized into 2,889 pathways involving 32,565 proteins and modified forms of proteins encoded by 11,496 different human genes, 16,325 complexes, 2,178 small molecules, and 1,103 drugs.
    reactome.org ·
    Reactome comprises 16,503 human reactions organized into 2,889 pathways involving 32,565 proteins and modified forms of proteins encoded by 11,496 different human genes, 16,325 complexes, 2,178 small molecules, and 1,103 drugs.

    https://reactome.org/about/news · Dataset page · checked 2026-11-13

  • The page states that these reactions were projected onto 83,732 orthologous proteins, creating 20,751 orthologous pathways in 14 non-human species.
    reactome.org ·
    We have projected these reactions onto 83,732 orthologous proteins, creating 20,751 orthologous pathways in 14 non-human species.

    https://reactome.org/about/news · Dataset page · checked 2026-11-13

Identifiers

  • stable identifiersThe download page lists a stable identifiers database.
    reactome.org ·
    Stable identifiers database

    https://reactome.org/download-data · Dataset page · checked 2026-11-13

  • → UniProtThe page lists the entry UniProt to pathways.
    reactome.org ·
    UniProt to pathways

    https://reactome.org/download-data · Dataset page · checked 2026-11-13

  • → ChEBIThe page lists the entry ChEBI to pathways.
    reactome.org ·
    ChEBI to pathways

    https://reactome.org/download-data · Dataset page · checked 2026-11-13

  • → ENSEMBLThe page lists the entry ENSEMBL to pathways.
    reactome.org ·
    ENSEMBL to pathways

    https://reactome.org/download-data · Dataset page · checked 2026-11-13

  • → miRBaseThe page lists the entry miRBase to pathways.
    reactome.org ·
    miRBase to pathways

    https://reactome.org/download-data · Dataset page · checked 2026-11-13

  • → NCBIThe page lists the entry NCBI to pathways.
    reactome.org ·
    NCBI to pathways

    https://reactome.org/download-data · Dataset page · checked 2026-11-13

  • → GtoPThe page lists the entry GtoP to pathways.
    reactome.org ·
    GtoP to pathways

    https://reactome.org/download-data · Dataset page · checked 2026-11-13

  • → OMIMThe page lists the entry Reactome to OMIM.
    reactome.org ·
    Reactome to OMIM

    https://reactome.org/download-data · Dataset page · checked 2026-11-13

  • → BioModelsThe page lists the entry BioModels to Pathways.
    reactome.org ·
    BioModels to Pathways

    https://reactome.org/download-data · Dataset page · checked 2026-11-13

Access

  • Web interface onlyreactome.org

    Same terms as the card's license.

  • Bulk downloadreactome.org BioPAX · PSI-MITAB · SBML · SBGN

    Same terms as the card's license.

  • Database dumpreactome.org

    Same terms as the card's license.

  • Web interface onlyreactome.org

    Same terms as the card's license.

Versions

  • Update cycleThe page states that the Zenodo download directory is created for every Reactome release quarterly, starting from version 89 (06/2024), and contains download files.
    reactome.org ·
    The Zenodo download directory is created for every Reactome (reactome.org) release quarterly, starting from version 89 (06/2024), containing download files.

    https://reactome.org/download-data · Dataset page · checked 2026-11-13

  • Breaking changeThe page notes that, as of Reactome V94, the Events in BioPAX level 2 format will no longer be available.
    reactome.org ·
    Note: As of Reactome V94, the “Events in BioPAX level 2 format" will no longer be available.

    https://reactome.org/download-data · Dataset page · checked 2026-11-13

  • Breaking changeThe page notes that, as of Reactome V94, the Protégé 2.0 ontology files will no longer be available.
    reactome.org ·
    Note: As of Reactome V94, the “Protégé 2.0 ontology files” will no longer be available.

    https://reactome.org/download-data · Dataset page · checked 2026-11-13

Known defects and misuse

  • The page states that interactions are inferred between all protein components of a complex and that, to limit the creation of false-positive inferences, only complexes with four or fewer protein components are considered.
    reactome.org ·
    Interactions are inferred between all protein components of a complex. To limit the creation of false-positive inferences, only complexes with four or fewer protein components are considered.

    https://reactome.org/download-data · Dataset page · checked 2026-11-13

Suited for

  • The page states that the services and software tools are designed for biologists, bioinformaticians, and software developers.
    reactome.org ·
    Our services and software tools are designed for biologists, bioinformaticians, and software developers.

    https://reactome.org/about/news · Dataset page · checked 2026-11-13

  • The page states that the Reactome FIViz app and ReactomeGSA package provide tools for multi-omics data analysis.
    reactome.org ·
    The Reactome FIViz app and ReactomeGSA package provide tools for multi-omics data analysis.

    https://reactome.org/about/news · Dataset page · checked 2026-11-13

Tags

Source type
Built from a knowledge base

Author-statedInferredHuman-confirmed

Reactome license evidence 20

Conditions are the union of the parts

  1. Terms of use pagePage opened
    Third-party text · Terms of use pageThis License Agreement (the “Agreement”) governs the use of the Reactome database and its contents, including all data, graphics, software, and other materials associated therewith.

    Statement found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  2. Terms of use pagePage opened
    Third-party text · Terms of use pageIf you do not agree with the terms of this Agreement, you may not use Reactome.

    Statement found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  3. Terms of use pagePage opened
    Third-party text · Terms of use pageUser agrees that the content on Reactome is governed by various open-source licenses and agrees to adhere to applicable license terms as follows:

    Statement found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  1. Terms of use pagePage opened
    CC-BY-4.0
    Third-party text · Terms of use pageThis Reactome content is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0)

    Statement found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  2. Terms of use pagePage opened
    Third-party text · Terms of use pageUser may copy, modify, and distribute these materials, provided that appropriate credit is given, a link to the license is included, and any modifications made by User are clearly indicated.

    Statement found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  3. Terms of use pagePage opened
    Apache-2.0
    Third-party text · Terms of use pageall Reactome software is licensed under the Apache License 2.0

    Statement found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  4. Terms of use pagePage opened
    Third-party text · Terms of use pageIndividual repositories are marked with the appropriate licensing requirements, and User must ensure their intended use is compliant with the relevant license, as applicable.

    Statement found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  5. Terms of use pagePage opened
    CC0-1.0
    Third-party text · Terms of use pageAll data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0)

    Statement found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  6. Terms of use pagePage opened
    Third-party text · Terms of use pageUser may copy, modify, and distribute these data, even for commercial purposes, without asking for permission.

    Statement found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  7. Terms of use pagePage opened
    Third-party text · Terms of use pageAttribution is encouraged but not required.

    Statement found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  8. Terms of use pagePage opened
    Third-party text · Terms of use pageNotwithstanding the Applicable Open-Source Licenses set out in Section 1 above, User agrees to the application of Special Licenses to certain Reactome content as follows:

    Statement found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  9. Terms of use pagePage opened
    Third-party text · Terms of use pageThe FoamTree software, used to construct the ReacFoam genome-wide pathway overview, is provided under license by Carrot Search, Inc.

    Statement found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  10. Terms of use pagePage opened
    Third-party text · Terms of use pageImages and analyses generated on the Reactome website using FoamTree software are free to use with no restriction.

    Statement found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  11. Terms of use pagePage opened
    Third-party text · Terms of use pageFor local installations of the Reactome, User must either: i) use the free, fully functional demo version of the FoamTree software included with Reactome, which adds a promotional logo to one of the cells of the visualization; or ii) obtain their own license from Carrot Search directly.

    Statement found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  12. Terms of use pagePage opened
    Third-party text · Terms of use pageReactome is provided “as is” and “as available” without any warranties of any kind, either express or implied.

    Statement found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  13. Terms of use pagePage opened
    Third-party text · Terms of use pageUsers must comply with all applicable licensing requirements and ensure that their access and/or use of Reactome content is consistent with the terms of this Agreement.

    Statement found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  14. Terms of use pagePage opened
    Third-party text · Terms of use page© 2026

    Statement found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  15. Terms of use pagePage opened
    Third-party text · Terms of use pageThis Reactome content is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0) .

    Statement found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  16. Dataset pagePage opened
    CC0-1.0
    Third-party text · Dataset pagec) Data : All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0) .

    Part "Data" found in snapshot s02 (page)

    reactome.org2026-11-13 · s02
  17. Dataset pagePage opened
    CC-BY-4.0
    Third-party text · Dataset pagea) Pathway Illustrations, Icon Library, Art, and Branding Materials . This Reactome content is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0) .

    Part "Pathway Illustrations, Icon Library, Art" found in snapshot s02 (page)

    reactome.org2026-11-13 · s02

Source and lineage

No upstream or downstream datasets recorded.

Known issues with Reactome

—

Preflight

Not run Runs only on ingested data; says nothing about quality.

Downloading Reactome and API access

No file on Mdexa (see the verdict). Get it from the source and confirm the terms there:

Latest V98

Citing Reactome

Mdexa, Reactome, https://mdexa.com/datasets/reactome/, verified 2026-11-14.
More citation details

The source gives no citation text; the line above cites this card.

Machine-readable

reactome.jsonreactome.mdcatalog.json

Change log 1
2026-11-14Listed on 2026-11-14. Judged by public rules and checked a second time before listing. The two passes disagreed; the stricter reading is carried: Second pass: license_status: looser by the source's own words (looser-explicit): 【标准许可误作自定义条款】许可协议第1条c款写明全部数据及其派生文件采用 CC0，可复制、修改、分发，甚至用于商业，无需许可；插图等为 CC BY 4.0；软件为 Apache 2.0。唯一的"特别许可"针对 FoamTree 软件的本地安装，属配套软件（第21条），不参与数据状态。"不同意即不得使用"是接受条款，不是甲类限制。数据部分没有甲类句，按原文应为 permissive（标识 CC0-1.0），插图部分 CC BY 4.0 带 attribution；比拟定更宽，原文明示，交采纳环节放宽。 | commercial_use: looser by the source's own words (looser-explicit): 原文明示数据"even for commercial purposes"可用，按原文应为 yes。 | derivatives: looser by the source's own words (looser-explicit): 原文明示可修改（modify），按原文应为 yes。 | redistribution: looser by the source's own words (looser-explicit): 原文明示可分发（distribute），按原文应为 yes。

Datasets similar to Reactome

  • STRINGVerified by MdexaEvaluation PermissiveLink only —

    License permissive, judged by public rules and checked by a second-pass model. Link only.

    Genomics and omics · Databases

    Open the cardSave

    Shared: Source type Built from a knowledge base · domain Genomics and omics · content Databases

  • AlphaFold Protein Structure DatabaseVerified by MdexaRetrieval knowledge baseWith evidence citations PermissiveLink only —

    License permissive: first-hand data-scope statement(s) allow commercial use and redistribution. Risk flag(s): derived, Model-generated. Link only.

    Genomics and omics · Databases · Derived · Model-generated

    Open the cardSave

    Shared: domain Genomics and omics · content Databases

  • GEOVerified by MdexaRetrieval knowledge base UnstatedPending —

    License unstated, judged by public rules and checked by a second-pass model. The license question stays open.

    Genomics and omics · Databases

    Open the cardSave

    Shared: domain Genomics and omics · content Databases

  • gnomADVerified by MdexaRetrieval knowledge base PermissiveLink only —

    License permissive, judged by public rules and checked by a second-pass model. Link only.

    Genomics and omics · Databases

    Open the cardSave

    Shared: domain Genomics and omics · content Databases

  • GTExVerified by Mdexa UnstatedPending —

    License unstated, judged by public rules and checked by a second-pass model. The license question stays open.

    Genomics and omics · Databases · Real patient text

    Open the cardSave

    Shared: domain Genomics and omics · content Databases

No sourced statement yet

Latest version · Unsuited tasks · Commercial licensing