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License status and Mdexa hosting, recorded separatelyAll datasets

UniProt

Verified by Mdexa · Checked against the source text under public rules.How we check

Commercial use
Yes
Derivatives
Yes
Redistribution
Yes
File on Mdexa
NoLink only

first-hand data-scope statement(s) allow commercial use and redistribution

PermissiveLink onlyCC-BY-4.0Save

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Mdexa verified · Permissive · 2026-11Mdexa verifiedPermissive · 2026-11

[![Mdexa verified · Permissive · 2026-11](https://mcp.mdexa.com/v1/badge/datasets/uniprot.svg)](https://mdexa.com/datasets/uniprot/)

Place it on a repository or dataset page; the status and date follow the verification. About badges

Cite this pageMdexa, UniProt, https://mdexa.com/datasets/uniprot/, verified 2026-11-13.

Key facts

Domain
Genomics and omics Modern medicine
Content
DatabasesUniProt (Universal Protein Resource) is a comprehensive catalog of information on proteins.
Size
—As stated: 154,222,205 entries
Language / modality
English / Text
Publisher
UniProt Consortium
Year
2026_04
Expert review
—
Verification
Partially verified

Commercial use of UniProt

Commercial use: Yes. License status: Permissive.

Conditions
Attribution
Third-party rights
The source notes that some content may carry third-party rights.

Quoted statements and their sources are in UniProt license evidence.

Verdicts record what sources state and are not legal advice.

Practical information

Content scope

Access

Versions

  • LatestThe announced UniProt Knowledgebase (UniProtKB) release is Release 2026_04, dated 04-Nov-2026.
    ftp.uniprot.org ·
    is pleased to announce UniProt Knowledgebase (UniProtKB) Release 2026_04 (04-Nov-2026).

    https://ftp.uniprot.org/pub/databases/uniprot/current_release/relnotes.txt · release-notes · checked 2026-11-13

  • Breaking changeUniProt announced in its 2025 NAR paper the intention to restrict unreviewed (TrEMBL) entries to reference proteomes, expecting an initial drop in unreviewed entry counts; excluded sequences remain in UniParc.
    pmc.ncbi.nlm.nih.gov ·
    It is our intention in 2025 to limit the unreviewed sequences in UniProtKB/TrEMBL to only those derived from reference proteomes

    https://pmc.ncbi.nlm.nih.gov/articles/PMC11701636/ · peer-reviewed-paper · checked 2026-11-13

  • Breaking changeEarlier, proteome-redundancy reduction has removed proteins from redundant proteomes since release 2015_04.
    rest.uniprot.org ·
    Methods to reduce proteome redundancy have been in effect since release 2015_04.

    https://rest.uniprot.org/help/proteome_redundancy · Dataset page · checked 2026-11-13

  • Breaking changeUniRef clustering changed in 2013: before then there was no 80% overlap threshold, so older clusters were more length-heterogeneous.
    rest.uniprot.org ·
    Prior to 2013 there was no overlap threshold, so clusters were more heterogeneous in length.

    https://rest.uniprot.org/help/uniref · Dataset page · checked 2026-11-13

Known defects and misuse

  • Schnoes et al. found Swiss-Prot near 0% misannotation for most of 37 enzyme families, while TrEMBL, GenBank NR and KEGG showed 5%–63% average misannotation across six superfamilies.
    pmc.ncbi.nlm.nih.gov ·
    the two other protein sequence databases (GenBank NR and TrEMBL) and the protein sequences in the KEGG pathways database exhibit similar and surprisingly high levels of misannotation that average 5%–63% across the six superfamilies studied.

    https://pmc.ncbi.nlm.nih.gov/articles/PMC2781113/ · peer-reviewed-paper · checked 2026-11-13

  • UniProt states TrEMBL entries are computationally annotated by automated systems, unlike reviewed Swiss-Prot entries.
    pmc.ncbi.nlm.nih.gov ·
    In the latter, entries are computationally annotated by automated systems.

    https://pmc.ncbi.nlm.nih.gov/articles/PMC11701636/ · peer-reviewed-paper · checked 2026-11-13

Suited for

  • UniProt recommends UniRef90/UniRef50 for similarity searches because they reduce redundancy while keeping full sequence-space coverage (about 58% and 79% size reduction).
    rest.uniprot.org ·
    UniRef, especially UniRef90 and UniRef50, decreases sequence redundancy compared to UniProtKB and UniParc, while maintaining complete coverage of the sequence space.

    https://rest.uniprot.org/help/uniref_blast_use · Dataset page · checked 2026-11-13

UniProt license evidence 3

  1. Terms of use pagePage opened
    CC-BY-4.0
    Third-party text · Terms of use pageWe have chosen to apply the Creative Commons Attribution 4.0 International (CC BY 4.0) License to all copyrightable parts of our databases.

    Statement found in snapshot s10 (terms-page)

    uniprot.org2026-11-13 · s10
  2. Terms of use pagePage opened
    Third-party text · Terms of use pageWe cannot provide unrestricted permission regarding the use of the data, as some data may be covered by patents or other rights.

    Statement found in snapshot s10 (terms-page)

    uniprot.org2026-11-13 · s10
  3. Terms of use pagePage opened
    Third-party text · Terms of use pageAny medical or genetic information is provided for research, educational and informational purposes only.

    Statement found in snapshot s10 (terms-page)

    uniprot.org2026-11-13 · s10

Source and lineage

No upstream or downstream datasets recorded.

Known issues with UniProt

  • Publisher states it makes no warranties about the correctness of the data and disclaims liability for damages resulting from its use.
  • The license help page snapshot shows only a generic fallback message, not the license text.

Preflight

Not run Runs only on ingested data; says nothing about quality.

Downloading UniProt and API access

No file on Mdexa (see the verdict). Get it from the source and confirm the terms there:

Latest 2026_04 · 2026-11-04 · 12 files

Citing UniProt

Mdexa, UniProt, https://mdexa.com/datasets/uniprot/, verified 2026-11-13.
More citation details

The source gives no citation text; the line above cites this card.

Machine-readable

uniprot.jsonuniprot.mdcatalog.json

Change log 8
2026-11-14Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is.
2026-11-14Practical fields (scope, identifiers, access methods, versions, known defects) were added by the automated pipeline from stored page snapshots; every statement carries a verbatim quote.
2026-11-14Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is.
2026-11-14Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is.
2026-11-14Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is.
2026-11-14Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is.
2026-11-14Known defects, version notes and access statements from cited sources (papers, release notes, official pages) were added; each shows who said it, when, and what kind of source it is.
2026-11-13Listed on 2026-11-13. Judged by public rules and checked a second time before listing. These pages could not be retrieved: the UniProt FTP knowledge base README and the UniRef README (connection timed out), and the help pages on API access and downloads (they returned only a script shell). The conclusion rests on the pages that were retrieved: the UniProt license page and the release notes.

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